高等学校化学学报 ›› 1989, Vol. 10 ›› Issue (12): 1202.

• 研究论文 • 上一篇    下一篇

N-(2,2,5,5-四甲基-3-吡咯啉-1-氧自由基)-N-(酰胺基)脲化合物的合成及抗癌活性

张自义1, 魏陆林1, 刘力生2, 郑荣梁2   

  1. 1. 兰州大学化学系;
    2. 兰州大学生物系
  • 收稿日期:1988-06-19 出版日期:1989-12-24 发布日期:1989-12-24
  • 通讯作者: 张自义

Studies on the Synthesis and Anticancer Activity of N-Carbamoyl-N'-(1-Oxyl-2,2,5,5-Tetramethyl-Pyrrolin-3-yl)Urea Compounds

Zhang Ziyi1, Wei Lulin1, Liu Lisheng2, Zheng Rongliang2   

  1. 1. Department of Chemistry, Lanzhou University, Lanzhou;
    2. Department of Biology, Lanzhou University, Lanzhou
  • Received:1988-06-19 Online:1989-12-24 Published:1989-12-24

摘要: 本文合成19个新的N-(2,2,5,5-四甲基-3-吡咯啉-1-氧自由基)-N-(酰胺基)脲化合物.研究了此类化合物的ESR,MS及IR波谱性质.初步观察了此类化台物对白血病L7712癌细胞以及腹水型肝癌细胞的抑制作用.发现有的化合物抑制效果显著.

关键词: 吡咯啉氮氧自由基, 异氰酸酯, 抗癌活性

Abstract: By the addition of l-oxyl-2, 2, 5, 5-tetramethyl-pyrroline-3-isocyanate (I), synthesized by seven steps,to substituted hydrazides with biological activity, nineteen N-carbamoyl-N'-(1-oxyl-2,2,5,5-tetramethyl-pyrrolin-3-yl) urea compounds were synthesized, The characteristics of electron spin resonance spectra, infrared spectra and mass spectra of some typical compounds of (Ⅲ) were discussed.The preliminary experiment showed that compounds (Ⅲ) possess a inhibiting activity on L7712-leukemia cell and ascitic hepatoma.Especially, the activity of (Ⅲ)e, as well as of (Ⅲ)g are more striking.

Key words: Pyrroline nitroxyi radical, Isocyanate, Anticancer activity

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