关键词: 纳米簇, 肾脏清除, 生物安全性, 肿瘤摄取, CT成像

Abstract: In this work, biocompatible and biodegradable sodium alginate (SA) was used to stabilize Au nanoclusters (NCs). Combined with the chemical inertness of Au, SA-AuNCs of 4.2±0.9 nm in diameter exhibited extremely low cytotoxicity. After administrated into mice, SA could delay the renal clearance of SA-AuNCs and prolong the half-life to 8.2±0.2 h in blood circulation. Thus the tumor uptake rate was increased to 10.4% ID/g. When tumor area contained high concentration of calcium ions, the tumor uptake rate could be further improved to 14.5% ID/g due to cross-link between Ca2+ and SA. The SA-AuNCs were mainly excreted through renal clearance, which only involved minor, but recoverable interference to the renal function. This indicates good biosafety of SA-AuNCs. This work can solves the contradiction between the renal clearance and tumor uptake of nanoclusters by using functional of ligands, which provides theoretical guidance for other high-performance diagnostic and therapeutic nanomaterials.

Key words: Nanoclusters, Renal Clearance, Biosafety, Tumor Uptake, CT Imaging