高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (10): 2211.doi: 10.7503/cjcu20200521

• 研究论文 • 上一篇    下一篇

2, 2, 6, 6-四甲基哌啶氧化物催化的高选择性羟基氧化反应

王怡博1,2, 黄大富2, 梁子颢2, 丁凯1()   

  1. 1.中国科学院上海有机化学研究所, 天然产物有机合成化学院重点实验室, 上海 200032
    2.中山俊凯生物技术开发有限公司, 中山 528437
  • 收稿日期:2020-08-03 出版日期:2020-10-10 发布日期:2020-10-08
  • 通讯作者: 丁凯 E-mail:dingkai@mail.sioc.ac.cn

Highly Selective TEMPO-catalyzed Hydroxyl Oxidation

WANG Yibo1,2, HUANG Dafu2, LIANG Zihao2, DING Kai1()   

  1. 1.CAS Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,Shanghai 200032,China
    2.Zhongshan Junkai Biotechnology Co. ,Ltd. ,Zhongshan 528437,China
  • Received:2020-08-03 Online:2020-10-10 Published:2020-10-08
  • Contact: DING Kai E-mail:dingkai@mail.sioc.ac.cn

摘要:

次氯酸钠在2,2,6,6-四甲基哌啶氧化物(TEMPO)的催化下, 可在温和的条件下选择性氧化胆酸类化合物的C3位羟基. 该方法提供了与常规的氧化剂相反的区域选择性, 为胆酸类化合物的结构改造提供了简洁的路线.

关键词: 2,2,6,6-四甲基哌啶氧化物, 次氯酸钠, 胆酸, 区域选择性, 羟基氧化

Abstract:

Sodium hypochlorite highly selectively oxidizes 3,7-dihydroxyl groups in the cholic acids in the presence of (2,2,6,6-tetramethylpiperidin-1-yl)oxyl(TEMPO) under mild conditions to offer 3-hydroxyl products with high yields. Contrary to the conventional oxidants, the high selectivity of the oxidant provides a more concise route for the conversion of cholic acid compounds.

Key words: (2, 2, 6, 6-Tetramethylpiperidin-1-yl)oxyl(TEMPO), NaClO, Cholic acid, Regioselectivity, Hydroxyl oxidation

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