闭合式无线纳米孔电极的一步法制备及单颗粒检测研究

doi:10.7503/cjcu20190339

高等学校化学学报 ›› 2019, Vol. 40 ›› Issue (10): 2075.doi: 10.7503/cjcu20190339

闭合式无线纳米孔电极的一步法制备及单颗粒检测研究

许素文¹,应佚伦^1,^2,^*(),龙亿涛²

^1. 华东理工大学化学与分子工程学院, 上海 200237
^2. 南京大学化学化工学院, 生命分析化学国家重点实验室, 南京 210023

收稿日期:2019-06-17 出版日期:2019-09-12 发布日期:2019-09-12
通讯作者: 应佚伦 E-mail:yilunying@nju.edu.cn
基金资助:
国家自然科学基金(Nos.61871183);国家自然科学基金(Nos.21834001)

One-step Method for Fabrication of Closed Wireless Nanopore Electrode and Its Application on Single Nanoparticle Detection ^†

XU Suwen¹,YING Yilun^1,^2,^*(),LONG Yitao²

^1. School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China
^2. School of Chemistry and Chemical Engineering, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210023, China

Received:2019-06-17 Online:2019-09-12 Published:2019-09-12
Contact: YING Yilun E-mail:yilunying@nju.edu.cn
Supported by:
† Supported by the National Natural Science Foundation of China.(Nos.61871183);† Supported by the National Natural Science Foundation of China.(Nos.21834001)

摘要/Abstract

摘要：

以锥形石英固体纳米孔为模板, 通过化学法制备具有金纳米结构的纳米孔尖端, 从而实现一步法简单、快速地制备直径为30 nm的闭合式无线纳米孔电极(CWNE); 探讨了制备过程中反应物浓度对制备过程的影响, 制备成功率高达85.7%, RMS噪音低至4.2 pA. 以金纳米颗粒碰撞电极实验为电化学测量模型, 获得了单个颗粒与纳米孔电极相互作用的信号, 验证了闭合式无线纳米孔电极对微秒级电信号的皮安级电流分辨能力, 为进一步探索纳米界面上的电子传递过程提供了稳定的测量界面.

关键词: 无线纳米孔电极, 电化学限域, 纳米电化学, 单个体电化学

Abstract:

We developed a one-step method based on the chemical reduction of HAuCl₄ to fabricate a closed wireless nanoelectrode(CWNE) which provides a high reproducibility in both electrode size and signal-to-noise ratio. By studing the reactant concentration, the successful ratio for fabricating 30 nm CWNE is increased to 85.7% and RMS noise value is decreased to 4.2 pA. Furthermore, the CWNE was applied in the single nanoparticle collision detection which shows a high current resolution at picoampere level and a high temporal resolution at microsecond level. Therefore, the CWNE could be further benefit to achieve the accurate nano-electrochemical measurements.

Key words: Wireless nanopore electrode, Electrochemically confined effect, Nano-electrochemistry, Single entity electrochemistry

中图分类号:

O657.1

TrendMD:

许素文,应佚伦,龙亿涛. 闭合式无线纳米孔电极的一步法制备及单颗粒检测研究. 高等学校化学学报, 2019, 40(10): 2075.

XU Suwen,YING Yilun,LONG Yitao. One-step Method for Fabrication of Closed Wireless Nanopore Electrode and Its Application on Single Nanoparticle Detection ^†. Chem. J. Chinese Universities, 2019, 40(10): 2075.

图/表 4

Fig.1 Scheme of the fabrication of closed wireless nanopore electrode(CWNE)(A), SEM images of a bare quartz nanopore with a diameter of 30 nm(from top view)(B) and CWNE with a diameter of 30 nm(from top view)(C) The sprayed Pt is deposited on the outer wall of nanopipette for a clear SEM image.

Table 1 Samples obtained with different concentrations of HAuCl4 and NaBH4

Sample No.	1	2	3	4	5
c(HAuCl₄)/(mmol·L^-1)	1	10	10	20	20
c(NaBH₄)/(mmol·L^-1)	5	5	10	10	20

Fig.2 Fabrication characterization of CWNEs Monitoring the growth process of samples 1(A), 4(B) and 5(C) by I-t current trace; (D) I-V curves of CWNEs after fabrication; (E) successful ratio for samples 1—5, respectively.

Fig.3 Current response of 30 nm CWNE in the absence/presence of AuNPs The pentagram denotes the typical spike signals shown in the right.

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闭合式无线纳米孔电极的一步法制备及单颗粒检测研究

One-step Method for Fabrication of Closed Wireless Nanopore Electrode and Its Application on Single Nanoparticle Detection ^†

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闭合式无线纳米孔电极的一步法制备及单颗粒检测研究

One-step Method for Fabrication of Closed Wireless Nanopore Electrode and Its Application on Single Nanoparticle Detection †

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One-step Method for Fabrication of Closed Wireless Nanopore Electrode and Its Application on Single Nanoparticle Detection ^†