Synthesis of Metal Phthalocyanines Containing Piperidine and Their Photoinhibition on Cancer Cell

Chem. J. Chinese Universities

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Synthesis of Metal Phthalocyanines Containing Piperidine and Their Photoinhibition on Cancer Cell

HUANG Zi-Yang^1,2, XUE Jin-Ping¹, CHEN Jin-Can³, CHEN Nai-Sheng¹, HUANG Jin-Ling¹*

1. Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China;
2. College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China;
3. Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China

Received:2007-08-20 Revised:1900-01-01 Online:2008-03-10 Published:2008-03-10
Contact: HUANG Jin-Ling

Abstract

Abstract: “The template approach” was used for the synthesis of eight metal phthalocyanine complexes containing piperidine group(PEO)₄PcM, where M=Zn, Ni, Co, Cu, PEO=2-(piperidin-1-yl) ethyoxyl. These complexes were characterized by FTIR, mass spectrum, elemental analysis and so on. The UV-Vis absorption spectra, fluorescence emission spectra and capacity of photo-generating singlet oxygen were examined. The results showed that two zinc phthalocyanine complexes possessed high molar extinction coefficient, fluorescence quantum yield, high rate of photo-generating singlet oxygen. The complex with formula β-(PEO)₄PcZn had a photoinhibition effect to BEL7402 liver cancer cells up to 83% in case that the irradiation with 670 nm laser light(dosage 1.2 J) and the concentration of β-(PEO)₄PcZn with 10 μmol/L were used.

Key words: Metal phthalocyanine, N-Piperidineethanol, Synthesis, Photoinhibition

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HUANG Zi-Yang^1,2, XUE Jin-Ping¹, CHEN Jin-Can³, CHEN Nai-Sheng¹, HUANG Jin-Ling¹*. Synthesis of Metal Phthalocyanines Containing Piperidine and Their Photoinhibition on Cancer Cell[J]. Chem. J. Chinese Universities, doi: .

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Synthesis of Metal Phthalocyanines Containing Piperidine and Their Photoinhibition on Cancer Cell

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