Studies on Drugs Absorption Using Liposome to Simulate Biomembrane

Abstract

Abstract: The absorptions of liposoluble salicylic acid, water soluble vitamin B₆, ceftriaxone, quinolone antibacteria norfloxacin and anticancer medicine doxorubicin were discussed by using liposome as biomembrane model and comparison with cell membrane. The absorption of salicylic acid whose absorption curve is linear depends on the passive diffusion. The experimental result of vitamin B₆ supports the opinion that the absorption of vitam in B₆ depends on proteins which lie in membranes. The absorption of vitamin B₆ is a chemical process, so absorption curve is nonlinear. The absorption mode of ceftriaxone is a simple diffusion. The absorption of norfloxacin depends on the effects of metal ions. Under the driving force of nucleic acid in cells, doxorubicin was absorbed through biomembrane.

Key words: Liposome, Biomembrane model, Drug absorption

CLC Number:

O657

TrendMD:

LUO Yun-Jing, SHEN Han-Xi, LIU Hai-Tao, KONG De-Ming . Studies on Drugs Absorption Using Liposome to Simulate Biomembrane[J]. Chem. J. Chinese Universities, 1998, 19(11): 1730.

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Studies on Drugs Absorption Using Liposome to Simulate Biomembrane

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