Studies on the Design,Synthesis and Biological Activity of a Novel Type of Acylurea Compound

Chem. J. Chinese Universities ›› 1997, Vol. 18 ›› Issue (3): 395.

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Studies on the Design,Synthesis and Biological Activity of a Novel Type of Acylurea Compound

YANG Xin-Ling¹, WANG Dao-Quan¹, CHEN Fu-Heng¹, LING Yun¹, ZHANG Zhong-Ning², SHANG Zhi-Zhen³

1. Department of Applied Chemistry, China Agricultural University, Beijing, 100094;
2. Animal Institute, Acadenic Sinica, Beijing;
3. Institute of Elentento-Organic Chemistry, Nattkai Univrrsity, Tianjin

Received:1996-05-08 Online:1997-03-24 Published:1997-03-24

Abstract

Abstract: In order to find new insectlcldes possessing a high activity and excellent selectivity, a novel type of diacylurea containing furan has been designed and prepared.Thus, by the nucleophilic addition reaction of 5-substituted futamide and benzoyl isocyanate, 21 compounds of N-benzoyl-N'-[5-substituted furoyl]urea were obtained in 74.5 % ～ 99.5 % yield.Their structures were confirmed by elementary analysis, IR, ¹HNMR and MS.The result of preliminary bioassay demonstrates that some of them show chitin-inhibiting activity against mosqito larvae at 10 mg/L.Especially, compounds 1, 15 and 21 exhibited ＞8O%mortality to larval mosquitoes with the same dead symptom as IKI-7899.

Key words: Diacylurea, Design, Synthesis, Biological activity

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YANG Xin-Ling, WANG Dao-Quan, CHEN Fu-Heng, LING Yun, ZHANG Zhong-Ning, SHANG Zhi-Zhen. Studies on the Design,Synthesis and Biological Activity of a Novel Type of Acylurea Compound[J]. Chem. J. Chinese Universities, 1997, 18(3): 395.

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Studies on the Design,Synthesis and Biological Activity of a Novel Type of Acylurea Compound

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