Study of Two Sandwich-type Manganese Polyoxometalates as Potential MRI Contrast Agents

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Study of Two Sandwich-type Manganese Polyoxometalates as Potential MRI Contrast Agents

LI Zhong-Feng^1,2, LI Wei-Sheng^1,2, LIAO Pei-Qiu^1,2, WEI Lai^1,2, LI Xiao-Jing¹*, JING Feng-Ying¹, PEI Feng-Kui¹*, WANG Xu-Xia^2,3, LEI Hao³

1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China;
3. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China

Received:2007-05-10 Revised:1900-01-01 Online:2007-11-10 Published:2007-11-10
Contact: PEI Feng-Kui

Abstract

Abstract: Two sandwich-type manganese polyoxometalates, K₁₀[Mn₄(PW₉O₃₄)₂]·22H₂O and Na₁₆[Mn₄(H₂O)₂(P₂W₁₅O₅₆)₂]·53H₂O, were synthesized and characterized by IR and elemental analysis. T₁-relaxivities of the two compounds were higher than or similar to that of the commercial MRI contrast agent(Gd-DTPA), and relaxivities in BSA and hTf were also reported. T₁-weighted MR imaging of rat kidney and liver showed a good enhancement post i.v. injection of the two manganese polyoxometalates. The results indicate the two sandwich-type manganese polyoxometalates being potential contrast agents for MRI.

Key words: Sandwich-type manganese polyoxometalates, Magnetic resonance imaging, Contrast agent, Relaxivity

CLC Number:

O614
O657.2

TrendMD:

LI Zhong-Feng^1,2, LI Wei-Sheng^1,2, LIAO Pei-Qiu^1,2, WEI Lai^1,2, LI Xiao-Jing¹*, JING Feng-Ying¹, PEI Feng-Kui¹*, WANG Xu-Xia^2,3, LEI Hao³. Study of Two Sandwich-type Manganese Polyoxometalates as Potential MRI Contrast Agents[J]. Chem. J. Chinese Universities, doi: .

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Study of Two Sandwich-type Manganese Polyoxometalates as Potential MRI Contrast Agents

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