Synthesis of 2-Pyrazoyl-5-substituted-1,3,4-oxadiazoles and Their Biological Activities

Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (10): 1520.

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Synthesis of 2-Pyrazoyl-5-substituted-1,3,4-oxadiazoles and Their Biological Activities

CHEN Han-Song, LI Zheng-Ming, LI Jia-Feng

State Key Laboratory of Elemento Organic Chemistry, Institute of Elemento Organic Chemistry, Nankai Univeristy, Tianjin 300071, China

Received:1999-10-07 Online:2000-10-24 Published:2000-10-24

Abstract

Abstract: Aseries of 2-pyrazolyl-5-substituted-1,3,4-oxadiazoles were synthesized starting from 5-pyrazole formic acid hydrazide and carboxylic acid by one pot method in the presence of phosphorus oxychloride. Two 1-benzoyl-2-pyrazolylhydrazines were prepared from 5-pyrazole hydrazide. Preliminary bioassay indicated that some compounds showed certain fungicidal and herbicidal activities.

Key words: Pyrazolyl-1,3,4-oxadiazole, Linked biheterocycles, Synthesis, Biological activities

CLC Number:

O626.27

TrendMD:

CHEN Han-Song, LI Zheng-Ming, LI Jia-Feng . Synthesis of 2-Pyrazoyl-5-substituted-1,3,4-oxadiazoles and Their Biological Activities[J]. Chem. J. Chinese Universities, 2000, 21(10): 1520.

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Synthesis of 2-Pyrazoyl-5-substituted-1,3,4-oxadiazoles and Their Biological Activities

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