Synthesis and Characterization of Tridentate Polypyridyl Cobalt(Ⅲ) and Ruthenium(Ⅱ) Complexes and Its Interaction with DNA

Chem. J. Chinese Universities

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Synthesis and Characterization of Tridentate Polypyridyl Cobalt(Ⅲ) and Ruthenium(Ⅱ) Complexes and Its Interaction with DNA

YANG Hao

Department of Chemistry, Nanyang Normal University, Nanyang 473061, China

Received:2006-07-03 Revised:1900-01-01 Online:2007-05-10 Published:2007-05-10
Contact: YANG Hao

Abstract

Abstract: Two novel tridentate polypyridyl mixed-ligand cobalt(Ⅲ) [Co(PhTPY)(H₂Bzimpy)]³⁺(A) and ruthenium(Ⅱ) [Ru(PhTPY)(Bzimpy)](B) complexes were synthesized and characterized via elemental analysis and ¹H NMR. The crystal structure of complex B was determined. The interactions between the complexes and calf thymus DNA were investigated with absorption and fluorescence spectroscopys. Photoactivated cleavage of pBR322DNA by the synthesized complexes were studied. The spectrophotometric studies show that the modes of these two complexes interacting with DNA were electrostatic interaction. The agarose gel electrophoresis results show that complex A and complex B converted supercoiled pBR322DNA to nicked and linear DNA when irradiated by the light with a wavelengths 310 nm for 15 min, 450 nm for 4 min, respectively.

Key words: Tridentate polypyridine ligand, Cobalt(Ⅲ) and Ruthenium(Ⅱ) complexes, DNA, Electronic absorption spectrum, Fluorescence spectrum, Photocleavage

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YANG Hao. Synthesis and Characterization of Tridentate Polypyridyl Cobalt(Ⅲ) and Ruthenium(Ⅱ) Complexes and Its Interaction with DNA[J]. Chem. J. Chinese Universities, doi: .

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Synthesis and Characterization of Tridentate Polypyridyl Cobalt(Ⅲ) and Ruthenium(Ⅱ) Complexes and Its Interaction with DNA

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