Gd3+ and RGD Functionalized Quantum Dots for Fluorescent and MR Dual-modality Imaging of Pancreatic Cancer Cells

doi:10.3969/j.issn.0251-0790.2012.02.029

Abstract

Abstract: Though early diagnosis of pancreatic cancer is difficult, it brings challenges and opportunities to the molecular imaging. The existing diagnostic imaging technologies are limited as a result of single functiona-lity, making it difficult for accurate diagnosis. In this work, magnetic resonance image(MRI) and fluorescence imaging were combined by several key contrast agents including gadolinium ion, quantum dots(QDs) and arginine(R)-glycine(G)-D-aspartic acid(D)(RGD) for high relaxation rate, strong fluorescent emission and good targeting. The integrated dual-modality QDs@Gd³⁺-RGD nanoprobes were used for dual-modality imaging of pancreatic cancer cells. TEM and dynamic light scattering(DLS) results indicate complete dispersion of QDs@Gd³⁺-RGD nanoprobes in water. In vitro relaxivity measurement shows high relaxation rate of QDs@Gd³⁺-RGD nanoprobes. Their r₁ and r₂ are 7.6 and 9.5 L@mmol^-1@s^-1, respectively. Fluorescent and MR dual-modality imaging suggest the prepared QDs@Gd³⁺-RGD nanoprobes can sever as both fluorescent and MR imaging of patu8988 pancreatic cancer cells.

Key words: Dual-modality imaging, Quantum dots, Arginine(R)-glycine(G)-D-aspartic acid(D)(RGD), Pancreatic cancer

CLC Number:

O648
Q503

TrendMD:

LIU Feng-Jun, ZHANG Bing-Bo, SONG Ge, CHENG Ying-Sheng. Gd³⁺ and RGD Functionalized Quantum Dots for Fluorescent and MR Dual-modality Imaging of Pancreatic Cancer Cells[J]. Chem. J. Chinese Universities, 2012, 33(02): 378.

References

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Gd³⁺ and RGD Functionalized Quantum Dots for Fluorescent and MR Dual-modality Imaging of Pancreatic Cancer Cells

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