Design, Synthesis and Biological Activities of Novel Anthranilic Isophthaloyl Amide

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (8): 1750.

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Design, Synthesis and Biological Activities of Novel Anthranilic Isophthaloyl Amide

YAN Tao, YU Guan-Ping, XIONG Li-Xia, YU Shu-Jing, WANG Su-Hua, LI Zheng-Ming*

State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Received:2010-10-08 Revised:2010-12-09 Online:2011-08-10 Published:2011-07-19
Contact: LI Zheng-Ming E-mail:nkzml@vip.163. com
Supported by:
国家“九七三”计划项目(批准号: 2010CB126106)和国家自然科学基金(批准号: 20872069)资助.

Abstract

Abstract: Chlorantraniliprole has been widely studied in the agrochemical field, which is significant in the field of crop protection, particularly important in light of the ability of insects to rapidly developresistance and the need for safe and effective pesticides that act at Ryanodine receptor. A series of novel anthranilic isophthaloyl amides developed from the structure of Chlorantraniliprole was designed and synthesized. Their structures were characterized by 1HNMR and HRMS. The preliminary results of biological activity experiment showed that compound 8d exhibited 60% insecticidal activity against Mythimna separata Walker at 200 mg?L-1; compound 8d exhibited 41.7% fungicidal activity against Physalospora piricola and compound 8a exhibited 41.2% fungicidal activityagainst Gibberella sanbinetti at 50 mg?L-1.

Key words: Chlorantraniliprole; , Anthranilic isophthaloyl amide; , Insecticidal activity; , Fungicidal activity

CLC Number:

O626.3

TrendMD:

YAN Tao, YU Guan-Ping, XIONG Li-Xia, YU Shu-Jing, WANG Su-Hua, LI Zheng-Ming*. Design, Synthesis and Biological Activities of Novel Anthranilic Isophthaloyl Amide[J]. Chem. J. Chinese Universities, 2011, 32(8): 1750.

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Design, Synthesis and Biological Activities of Novel Anthranilic Isophthaloyl Amide

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