Electrochemical Studies on Interaction Between Dinuclear Copper(Ⅱ) Complex Containing Dimethylglyoxime and DNA

Chem. J. Chinese Universities

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Electrochemical Studies on Interaction Between Dinuclear Copper(Ⅱ) Complex Containing Dimethylglyoxime and DNA

XU Gui-Yun^1,2, JIAO Kui², LI Yan-Tuan³, REN Yong², ZHANG Xu-Zhi²

1. College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266003, China;
2. College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China;
3. Institute of Marine Drug and Food, Ocean University of China, Qingdao 266003, China

Received:2006-01-06 Revised:1900-01-01 Online:2007-01-10 Published:2007-01-10
Contact: JIAO Kui

Abstract

Abstract: Cyclic voltammetry was used to study the interaction between dinuclear copper(Ⅱ) complex containing dimethylglyoxime[Cu₂(Hdmg)₄] and DNA. The influences of pH, temperature, ionic strength and concentration of Cu₂(Hdmg)₄ on the interaction were described, and the mechanism of the interaction was also discussed. The result shows that Cu₂(Hdmg)₄ can interact with the bases of DNA to form non-electroactive complex, which can decrease the anodic peak current of Cu₂(Hdmg)₄. The interaction between Cu₂(Hdmg)₄ and ssDNA is stranger than that between Cu₂(Hdmg)₄ and dsDNA because of the exposed bases of ssDNA. The combining ratios of Cu₂(Hdmg)₄ to ssDNA and to dsDNA are 2:1 and 1:1, and the combining constants 3.56×10⁹ and 2.75×10⁵, respectively.

Key words: Dinuclear copper(Ⅱ) complex, Dimethylglyoxime, DNA, Cyclic voltammetry, Interaction

CLC Number:

O657.1

TrendMD:

XU Gui-Yun^1,2, JIAO Kui², LI Yan-Tuan³, REN Yong², ZHANG Xu-Zhi². Electrochemical Studies on Interaction Between Dinuclear Copper(Ⅱ) Complex Containing Dimethylglyoxime and DNA[J]. Chem. J. Chinese Universities, doi: .

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Electrochemical Studies on Interaction Between Dinuclear Copper(Ⅱ) Complex Containing Dimethylglyoxime and DNA

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