Synthesis of PEI-conjugated BaGdF5 Nanoparticle for in vivo Dual-modal MR and CT Imaging†

doi:10.7503/cjcu20180357

Abstract

Abstract:

PEI-conjugated BaGdF₅ nanoparticles were synthesized via a one-pot facile but efficient microwave-assisted polyol process. Transmission electron microscopy(TEM), X-ray diffraction(XRD), FTIR spectroscopy, cytotoxicity test, CT imaging and MR imaging were used to characterize these well-prepared nanoparticles. TEM images indicated that these nanoparticles held an average diameter of 30 nm with uniform spherical character and relatively smooth surface. MTT result indicated these nanoparticles showed a very low cytotoxicity. Both in vitro and in vivo imaging results demonstrated that these nanoparticles exhibited excellent dual-modal MR and CT imaging capabilities, indicating their potential applications in further clinical areas.

Key words: CT imaging, MR imaging, Nanoparticles, Contrast agent

CLC Number:

O614.8

TrendMD:

LIU Jianhua,SHI Zhan,LI Bo,ZHANG Tianqi,CUI Fengzhi,YUAN Qinghai. Synthesis of PEI-conjugated BaGdF₅ Nanoparticle for in vivo Dual-modal MR and CT Imaging^†[J]. Chem. J. Chinese Universities, 2018, 39(9): 1881.

Figures/Tables 5

Fig.1 TEM image(A), high resolution TEM image(B), XRD pattern(C) and FTIR spectrum(D) of PEI-BaGdF5

Fig.2 Cell viability(A) and concentration dependent hemolysis images of PEI-BaGdF5(B~E) (B) Control group; (C) 1 mg/mL group; (D) 2 mg/mL group; (E) 4 mg/mL group.

Fig.3 MTT image of PEI-BaGdF5(A—E) and histological images of PEI-BaGdF5(A'—E') (A, A') Heart; (B, B') liver; (C, C') lung; (D, D') spleen; (E, E') kidney.

Fig.4 In vitro CT image with different concentration of PEI-BaGdF5(A) and in vivo CT images of the mice before(B—E) and after(F—I) injection of PEI-BaGdF5(B, D, F, H) Liver; (C, E, G, I) kidney.

Fig.5 In vitro MR image(A), and in vivo MR images before(B) and 24 h after(C) injection of PEI-BaGdF5

References 21

[1]	Johnson P., Federico M., Kirkwood A., Fossa A., Berkahn L., Carella A., d’Amore F., Enblad G., Franceschetto A., Fulham M., Luminari S., O’Doherty M., Patrick P., Roberts T., Sidra G., Stevens L., Smith P., Trotman J., Viney Z., Radford J., Barrington S., N. Engl. J. Med., 2016, 374(25), 2419—2429
[2]	Kroisel P. M., Hausler M., Klaritsch P., Karpf E., Zebedin D., Tiran B., Pertl B., Wagner K., Lancet, 2017, 389(10081), 1857—1858
[3]	Elias W. J., Lipsman N., Ondo W. G., Ghanouni P., Kim Y. G., N. Engl. J. Med., 2016, 375(8), 730—739
[4]	Maier F. C., Wehrl H. F., Schmid A. M., Mannheim J. G., Wiehr S., Lerdkrai C., Calaminus C., Stahlschmidt A., Ye L., Burnet M., Stiller D., Sabri O., Reischl G., Staufenbiel M., Garaschuk O., Jucker M., Pichler B. J., Nat. Med., 2014, 20(12), 1485—1492
[5]	Mezer A., Yeatman J. D., Stikov N., Kay K. N., Cho N. J., Dougherty R. F., Perry M. L., Parvizi J., Hua L. H., Butts-Pauly K., Wandell B. A., Nat. Med., 2013, 19(12), 1667—1672
[6]	Peris A., Tutino L., Cianchi G., Gensini G., N. Engl. J. Med., 2018, 378(14), e19
[7]	Rutty G. N., Morgan B., Robinson C., Raj V., Pakkal M., Amoroso J., Visser T., Saunders S., Biggs M., Hollingbury F., McGregor A., West K., Richards C., Brown L., Harrison R., Hew R., Lancet, 2017, 390(10090), 145—154
[8]	Hu Z., Yang B., Li T., Li J., Contrast Media Mol. Imaging, 2018, 2018, 8710862
[9]	Pimlott S. L., Sutherland A., Chem. Soc. Rev., 2011, 40(1), 149—162
[10]	Brenner D. J., Hall E. J., N. Engl. J. Med., 2007, 357(22), 2277—2284
[11]	Terreno E., Castelli D. D., Viale A., Aime S., Chem. Rev., 2010, 110(5), 3019—3042
[12]	Li F., Li C., Liu J., Liu X., Zhao L., Bai T., Yuan Q., Kong X., Han Y., Shi Z., Feng S., Nanoscale, 2013, 5(15), 6950—6959
[13]	Chen C., Liu J., Chen Y., Li C., Liu X., Huang H., Liang C., Lou Y., Shi Z., Feng S., ACS Appl. Mater. Interf., 2017, 9(7), 5748—5756
[14]	Ni D., Bu W., Ehlerding E. B., Cai W., Shi J., Chem. Soc. Rev., 2017, 46(23), 7438—7468
[15]	Park J., Xu M., Li F., Zhou H. C., J. Am. Chem. Soc., 2018, 140(16), 5493—5499
[16]	Liu Q., Xu M., Yang T., Tian B., Zhang X., Li F., ACS App. Mater. Interf., 2018, 10(12), 9883—9888
[17]	Dai Y., Xu C., Sun X., Chen X., Chem. Soc. Rev., 2017, 46(12), 3830—3852
[18]	Liu Y., Ji X., Tong W. W. L., Askhatova D., Yang T., Cheng H., Wang Y., Shi J., Angew. Chem. Int. Ed. Engl., 2018, 57(6), 1510—1513
[19]	Jin L., Liu J., Tang Y., Cao L., Zhang T., Yuan Q., Wang Y., Zhang H., ACS Appl. Mater. Interf., 2017, 9(48), 41648—41658
[20]	Gu T., Cheng L., Gong F., Xu J., Li X., Han G., Liu Z., ACS Appl. Mater. Interf., 2018, 10(18), 15494—15503
[21]	Sun L., Liu G. F., Zhuang J. Q., Zhang H. M., Yang W. S., Chem. J. Chinese Universities, 2010, 31(12), 2313—2315
	(孙琳, 刘桂锋, 庄家骐, 张惠茅, 杨文胜. 高等学校化学学报, 2010, 31(12), 2313—2315)

Synthesis of PEI-conjugated BaGdF₅ Nanoparticle for in vivo Dual-modal MR and CT Imaging^†

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 5

References 21

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Jinhan Sheng, Qizhen Zheng, Ming Wang. Non-viral delivery of CRISPR/Cas9 Genome Editing [J]. Chem. J. Chinese Universities, 2022, 43(Album-4): 20220344.
[2]	LIU Shuwei, JIN Hao, YIN Wanzhong, ZHANG Hao. Gemcitabine/polypyrrole Composite Nanoparticles for Chemo-photothermal Combination Ovarian Cancer Therapy [J]. Chem. J. Chinese Universities, 2022, 43(8): 20220345.
[3]	WANG Guangqi, BI Yiyang, WANG Jiabo, SHI Hongfei, LIU Qun, ZHANG Yu. Heterostructure Construction of Noble-metal-free Ternary Composite Ni（PO₃）₂-Ni₂P/CdS NPs and Its Visible Light Efficient Catalytic Hydrogen Production [J]. Chem. J. Chinese Universities, 2022, 43(6): 20220050.
[4]	WANG Hong, SAN Khin Nyein Ei, FANG Yun, ZHANG Xinyu, FAN Ye. Pickering Emulsion Stabilization and Interfacial Catalytic Oxidation by Janus Nano-Au [J]. Chem. J. Chinese Universities, 2022, 43(6): 20220105.
[5]	JI Fa, LIU Ling, YU Linling, SUN Yan. Effects of Muco-inert and Acid-sensitive Modification on Mucosal Penetration of Nanoparticles [J]. Chem. J. Chinese Universities, 2022, 43(6): 20210837.
[6]	SUN Xuefeng, RENAGUL Abdurahman, YANG Tongsheng, YANG Qianting. Synthesis and Luminescence Properties of Cr，In Co-doped Small Size MgGa₂O₄ Near-infrared Persistent Luminescence Nanoparticles [J]. Chem. J. Chinese Universities, 2022, 43(4): 20210850.
[7]	YANG Zhaohua, CHENG Hongjing, YANG Yi, LIU Hui, DU Feipeng, ZHANG Yunfei. Preparation of Silver-loaded Polyvinyl Alcohol Sponge and Its Interfacial Photothermal Driven Water Evaporation Performance [J]. Chem. J. Chinese Universities, 2022, 43(10): 20220181.
[8]	TAO Xingfu, HAN Chenglong, YANG Yang, LIU Kun. Synthesis of Aluminum Nanoparticles@Polymer Core-shell Nanostructures by Surface-initiated Polymerization [J]. Chem. J. Chinese Universities, 2022, 43(10): 20220367.
[9]	CHU Mingyue, LI Fengbo, GAO Ning, YANG Xin, YU Tingting, MA Huiyuan, YANG Guixin, PANG Haijun. Construction of a Coronal Polyoxometalate-based Composite Film for Determination of Nitrite [J]. Chem. J. Chinese Universities, 2022, 43(1): 20210579.
[10]	CHEN Shaoyun, ZHANG Xingying, LIU Ben, TIAN Du, LI Qi, CHEN Fang, HU Chenglong, CHEN Jian. Controllable Growth of Silver Nanoparticles on TiO₂ Tetragonal Prism Nanarrays and Its SERS Effect [J]. Chem. J. Chinese Universities, 2021, 42(8): 2381.
[11]	WANG Yawen, LI Dong, LIANG Wenkai, SUN Yinghui, JIANG Lin. Multiplex Structures of Plasmonic Metal Nanoparticles and Their Applications [J]. Chem. J. Chinese Universities, 2021, 42(4): 1213.
[12]	LIU Zhigang, LI Jiabao, YANG Jian, MA Hao, WANG Chengyin, GUO Xin, WANG Guoxiu. Preparation of a Novel g-C₃N₄/Sn/N-doped Carbon Composite for Sodium Storage [J]. Chem. J. Chinese Universities, 2021, 42(2): 633.
[13]	PAN Jing, XU Minmin, YUAN Yaxian, YAO Jianlin. Rapid Detection of Banned Dyes in Textiles Based on Surface-enhanced Raman Spectroscopy [J]. Chem. J. Chinese Universities, 2021, 42(12): 3716.
[14]	WANG Bodong, PAN Meichen, ZHUO Ying. Construction of Electrochemiluminescence Sensing Interface Based on Silver Nanoclusters-Silica Nanoparticles and Biomolecular Recognition [J]. Chem. J. Chinese Universities, 2021, 42(11): 3519.
[15]	SUN Qirui, ZHAO Nan, LIU Shuwei, XIN Hua, ZHANG Hao, ZHANG Lening. Polydopamine-coated Fe₃O₄/methylprednisolone/cyclophosphamide Superparticles for the Magnetic Targeting Treatment of Pulmonary Fibrosis [J]. Chem. J. Chinese Universities, 2021, 42(10): 3225.