Enantioseparation of Chiral Drugs by Cyclodextrin-Mediated Capillary Zone Electrophoresis

Abstract

Abstract:

The effects of the cyclodextrin (CD) type on the enantioseparation of six chiral drugs were investigated, using 2 natural CD, namely β-CD and γ-CD, 2 commonly used uncharged functionalized CD, namely hydroxypropylated β-CD (HP-β-CD) and dimethylated β-CD (DM-β-CD), and 3 newly-developed charged CD, namely highly sulfated α-CD (HS-α-CD), highly sulfated β-CD (HS-β-CD), highly sulfated γ-CD (HS-γ-CD) as capillary zone electrophoresis additive, respectively. While the 2 natural CD showed no enantioselectivity of the 6 chiral drugs, the functionalized CD's enantioselectivity improved greatly. In particular, the HS-β-CD could baseline chirally resolved the enantiomers of all the 6 chiral drugs, indicating that the HS-β-CD is a versatile chiral selector and is worth developing further. The effects of the pH of the background electrolyte and the organic modifier on the enantioseparation were also examined and disscussed.

Key words: Capillary electrophoresis, Enantiomer, Enantioselectivity, Cyclodextrin

CLC Number:

O658.9

TrendMD:

ZHANG Zhi-Chao, ZHANG Kai, JIANG Zheng-Jin, ZHOU Qi-lin, WANG Qin-Sunt, GAO Ru-Yu. Enantioseparation of Chiral Drugs by Cyclodextrin-Mediated Capillary Zone Electrophoresis[J]. Chem. J. Chinese Universities, 2001, 22(S1): 42.

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Enantioseparation of Chiral Drugs by Cyclodextrin-Mediated Capillary Zone Electrophoresis

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