Abstract:

To identify Fourier transform infrared(FTIR) spectra of normal and abnormal(mass) breast skin at molecular level, infrared scanning was performed for 46 healthy volunteers and 113 inpatients with palpable breast masses. Breast surface were measured by FTIR spectrometer equipped with attenuated total reflectance(ATR) probe and infrared optical fiber. The results showed that the spectra of healthy volunteers tended to be consistent; the FTIR spectra of control, benign and malignant groups differed owing to content or configuration alterations of nucleic acids, proteins, lipids and carbohydrates, and changes in differential diagnosis of benign and malignant were predominantly observed in the 1080 cm^-1 peak absorbance, commonly associated with nucleic acids.

Key words: Fourier transform infrared(FTIR) spectroscopy, Attenuated total reflectance(ATR), Optical fiber, Breast cancer