Synthesis, Crystal Structure, Antibacterial Activity and Interaction with BSA of Copper(Ⅱ) Complex with Ligand N,N'-Bis(4-chlorobenzyl)propane-1,2-diamine

doi:10.3969/j.issn.0251-0790.2012.01.002

Abstract

Abstract: A new copper(Ⅱ) complex with ligand N,N'-bis(4-chlorobenzyl)propane-1,2-diamine, ·NH₄·Cl₂, has been synthesized and characterized by elemental analysis, IR spectra and single crystal X-ray diffraction methods. The crystal of copper(Ⅱ) complex belongs to triclinic system with space group P1, a=1.35222(16)nm, b=1.37899(17)nm, c=1.39806(19)nm; α=60.954(1)°, β=87.502(2)°, γ=65.970(1)°, V=2.0424(4) nm³, D_c=1.357 g/cm³, Z=2, F(000)=862, R₁=0.0925, wR₂=0.2668, S=1.001. The copper(Ⅱ) atom of the metal center in complex is five-coordinated by four N atoms from two ligand molecules and a terminal Cl atom, and the coordination polyhedron around the Cu atom can be described as a slightly distorted square pyramid-geometry with a distortion index τ value of 0.04(1). The complex exhibited good antibacterial properties and the interaction of complex and bovine serum albumin(BSA) was investigated by fluorescence spectroscopy at different temperatures. The results indicated that the complex caused the fluorescence quenching of BSA through a static quenching procedure. The binding constants(K_a), the number of binding sites(n≈1), and corresponding thermodynamic parameters enthalpy change(ΔH＞0), entropy change(ΔS＞0), Gibbs free energy change(ΔG＜0), between complex and BSA at different temperatures were calculated. The primary binding pattern between complex and BSA was interpreted as hydrophobic interaction. The binding average distance r between the donor(BSA) and acceptor(complex) was obtained to be 2.56 nm based on the Föster's theory, which indicates the energy transfer can occur from BSA to complex with high probability.

Key words: Copper(Ⅱ) complex, N,N’-bis(4-chlorobenzyl)propane-1,2-diamine, Crystal structure, Antibacterial activity, Bovine serum albumin(BSA)

CLC Number:

O614.121

TrendMD:

YANG Shu-Ping, HAN Li-Jun, PAN Yan, WANG Da-Qi, ZHAO Cui, WANG Bo. Synthesis, Crystal Structure, Antibacterial Activity and Interaction with BSA of Copper(Ⅱ) Complex with Ligand N,N'-Bis(4-chlorobenzyl)propane-1,2-diamine[J]. Chem. J. Chinese Universities, 2012, 33(01): 14.

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