Interaction of Copolymer-paclitexal Conjugate Micelles with C6 Glioma Cells

Chem. J. Chinese Universities

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Interaction of Copolymer-paclitexal Conjugate Micelles with C₆ Glioma Cells

WANG Zhan-Feng¹, LUO Yi-Nan¹, ZHENG Yong-Hui², HAN Hai-Ling³, HONG Xin-Yu¹, JING Xia-Bin²*

1. Department of Neurosurgery, First Clinical Hospital, Jilin University, Changchun 130021, China;
2. State Key Lab of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
3. Department of Cardiac, Affiliated Hospital of Beihua University, Jilin 132011, China

Received:2007-12-18 Revised:1900-01-01 Online:2008-08-10 Published:2008-08-10
Contact: JING Xia-Bin

Abstract

Abstract: Nanoscale micelles of poly(ethylene)-b-poly(lactic acid)/paclitexal conjugate(PEG-PLA/PTX) were prepared and their interaction with rat brain glioma C₆ cells was examined by MTT, electron microscopy, flow cytometry(FCM), and confocal laser scanning microscopy(CLSM). The results show that the copolymer/paclitaxel conjugate micelles can enter the cell, and are distributed in cytoplasm. The paclitaxel can be released from the conjugate micelles and react with the genes in the cell nuclei, causing changes in the gene molecules, and thus, leading to changes in growth cycle of the cells, resulting in G₂-M cell cycle arrest and inducing apoptosis of C₆ cells. Therefore, PEG-PLA/PTX micelles may be used in chemotherapy of brain glioma.

Key words: Paclitaxel conjugate, Poly(ethylene)-b-poly(lactic acid) block copolymer, Flow cytometry, TEM, CLSM, Glioma C₆ cells, Apoptosis, Cell cycle

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WANG Zhan-Feng¹, LUO Yi-Nan¹, ZHENG Yong-Hui², HAN Hai-Ling³, HONG Xin-Yu¹, JING Xia-Bin²*. Interaction of Copolymer-paclitexal Conjugate Micelles with C₆ Glioma Cells[J]. Chem. J. Chinese Universities, doi: .

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Interaction of Copolymer-paclitexal Conjugate Micelles with C₆ Glioma Cells

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