Studies on Condensed Heterocyclic Compounds (Ⅳ)--Synthesis and Antibacterial Activity of 5-Formylamino-l-Aryl-1,2,3-Triazolo(2,3-d)Pyrimidin-4 one and Their Related Derivatives

Chem. J. Chinese Universities ›› 1991, Vol. 12 ›› Issue (10): 1344.

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Studies on Condensed Heterocyclic Compounds (Ⅳ)--Synthesis and Antibacterial Activity of 5-Formylamino-l-Aryl-1,2,3-Triazolo(2,3-d)Pyrimidin-4 one and Their Related Derivatives

Zhang Zi-yi¹, Liu Ying¹, Yang Shi-yan², Chen Mao-qi²

1. Department of Chemistry, Lanzhou University, Lanzhou, 730000;
2. Lanzhou Institute of Chemical Physics, Academia Sinica, Lanzhou

Received:1990-07-08 Online:1991-10-24 Published:1991-10-24

Abstract

Abstract: 5-Formylamino-1-aryl-1,2,3-triazolo(2, 3-d)pyrimidin-4-one (4_a,b,c) and 5-amino-6-hydroxyl-7H-1-(m-nitrophenyl)-1,2,3-triazolo(2,3-d)pyrimidin-4-one (5_d) have been synthesised fromthe reaction of 1-aryl-4-carbonhydrazide-5-amino-1, 2, 3-triazoles 3_a,b,c,dprepared by hydrazinolysis of either 1-aryl-4-ethoxycarbonyl-5-amino-1, 2, 3-triazoles 1_a,b,c,dor their benzoylamino derivatives (2_a,d), with an excess of formic acid under the fluxing condition. The structures of all heterocyclic compounds were confirmed by elemental analysis, IR,¹HNMR, MS, and the inhibiting effects on B. Substilis; E. coli; E. aerogenes;S. aureus were also screened.

Key words: Triazolopyrimidinone, Synthesis, Antibacterial activity

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Zhang Zi-yi, Liu Ying, Yang Shi-yan, Chen Mao-qi. Studies on Condensed Heterocyclic Compounds (Ⅳ)--Synthesis and Antibacterial Activity of 5-Formylamino-l-Aryl-1,2,3-Triazolo(2,3-d)Pyrimidin-4 one and Their Related Derivatives[J]. Chem. J. Chinese Universities, 1991, 12(10): 1344.

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Studies on Condensed Heterocyclic Compounds (Ⅳ)--Synthesis and Antibacterial Activity of 5-Formylamino-l-Aryl-1,2,3-Triazolo(2,3-d)Pyrimidin-4 one and Their Related Derivatives

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