Synthesis, Characterization and Biological Activity of Ethyl 2-Methyl-1-(4-arylthiazol-2-yl)-benzoimidazole-6-carboxylate

Chem. J. Chinese Universities

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Synthesis, Characterization and Biological Activity of Ethyl 2-Methyl-1-(4-arylthiazol-2-yl)-benzoimidazole-6-carboxylate

HU Ai-Xi¹*, HE Li-Min¹, DONG Min-Yu¹, ZHANG Jian-Yu^1,2, OU Xiao-Ming²

1. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China;
2. National Engineering Research Center for Agrochemicals, Changsha 410007, China

Received:2007-09-19 Revised:1900-01-01 Online:2008-04-10 Published:2008-04-10
Contact: HU Ai-Xi

Abstract

Abstract: Compounds containing thiazole or benzoimidazole ring system are found to exhibit a wide spectrum of biological activities. Fourteen new ethyl 2-methyl-1-(4-arylthiazol-2-yl)-benzoimidazole-6-carboxylates were synthesized from ethyl 4-acetamidobenzoate with four steps. Their structures were clearly established by MS, ¹H NMR spectra and elemental analysis. The crystal structure of compound 5a was determined by X-ray diffraction analysis. The preliminary bioassays indicate that compound 5c exhibited 95% inhibition rate against E. graminis at 500 mg/L; compound 5e exhibited 61.9% inhibition rate against P. capsici at 25 mg/L. compound 5e exhibited 97.2% inhibition rate against S. sclerotiorum at 500 mg/L, and compound 5k exhibited 55.1% inhibition rate against G. zeae.

Key words: Ethyl 2-methyl-1-(4-arylthiazol-2-yl)-benzoimidazole-6-carboxylate, Biological activity, Crystal structure

CLC Number:

O626.2

TrendMD:

HU Ai-Xi¹*, HE Li-Min¹, DONG Min-Yu¹, ZHANG Jian-Yu^1,2, OU Xiao-Ming². Synthesis, Characterization and Biological Activity of Ethyl 2-Methyl-1-(4-arylthiazol-2-yl)-benzoimidazole-6-carboxylate[J]. Chem. J. Chinese Universities, doi: .

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Synthesis, Characterization and Biological Activity of Ethyl 2-Methyl-1-(4-arylthiazol-2-yl)-benzoimidazole-6-carboxylate

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