Application of Polymers in Fluorescence Analysis†

doi:10.7503/cjcu20150796

Abstract

Abstract:

Polymers are macromolecular compounds built up from single or numerous kinds of monomers. The common materials in production and living(for example protein, nucleic acid, starch, fiber, plastic and rubber, etc.) are included in this category. Owing to the unique properties after polymerization and their monomers, polymers have been extensively used in fluorescence analysis as fundamental materials: target recognition can be realized through polymers interact with target molecules through intermolecular forces(hydrogen bond, hydrophilic and hydrophobic function, and van der Waals’ force, etc.); certein polymers can transform the molecular recognition event to easily recognizable fluorescence signal, and then fluorescence signal transformation and amplification could be realized; certein polymers have been used as framework of flourescence probes, therefore the recognition capacity of fluorescence probes are improved due to multivalency effect, and multifunction devices are constructed based on the conjugation of different functional units. In this paper, the research and application of polymers in molecular recognition, signal transformation and as framework of probes were reviewed.

Key words: Polymer, Fluorescence analysis, Molecular recognition, Signal transduction, Framework of fluorescence probe

CLC Number:

O652

TrendMD:

SONG Chunxia, YANG Xiaohai, WANG Kemin, WANG Qing, LIU Jianbo, HUANG Jin, LI Wenshan, HUANG Haihua, LIU Wei. Application of Polymers in Fluorescence Analysis^†[J]. Chem. J. Chinese Universities, 2016, 37(2): 201.

Figures/Tables 12

Fig.1 Application of polymers in fluorescence analyses[10—12] (C) Copyright(2010) from American Chemical Society; (D) Copyright(2014) from American Chemical Society; (E) Copyright(2013) from American Chemical Society.

Fig.2 Schematic diagram of recognition mechanism of the molecular imprinting process[16] Copyright(2011) from the Royal Society of Chemistry.

Fig.3 Dummy molecularly imprinted polymers-capped CdTe quantum dots for the fluorescent sensing of 2,4,6-trinitrotoluene[19] Copyright(2013) from American Chemical Society.

Fig.4 Proposed secondary structure of the thrombin aptamer(A) and the interaction of the aptamer with human thrombin(B) [26] Copyright(1997) from Academic Press.

Fig.5 Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration[28] Copyright(2011) from National Academy of Sciences.

Fig.6 Schematic diagram of signal transformation mechanism of the conjugated polymers[33] Copyright(2013) from American Chemical Society.

Fig.7 Direct detection of RDX vapor using a conjugated polymer network[49] Copyright(2013) from American Chemical Society.

Fig.8 Poly(thymine)-templated selective formation of fluorescent copper nanoparticles[75] Copyright(2013) from Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Fig.9 Competitive host-guest interaction(CHGI) between β-cyclodextrin polymer and pyrene-labeled probes for fluorescence analyses[88] Copyright(2015) from American Chemical Society.

Fig.10 Engineering polymeric aptamers for selective cytotoxicity[99] Copyright(2011) from American Chemical Society.

Fig.11 A smart and versatile theranostic nanomedicine platform based on nanoporphyrin[9] Copyright(2014) from Nature Publishing Group.

Fig.12 Self-assembled supramolecular nanoprobes for ratiometric fluorescence measurement of intracellular pH values[101] Copyright(2015) from American Chemical Society.

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