Ultrafine Fibrous Membranes by Coaxial Electrospinning for Artificial Blood Vessel

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (6): 1396.

• Articles • Previous Articles Next Articles

Ultrafine Fibrous Membranes by Coaxial Electrospinning for Artificial Blood Vessel

CAO Wen-Xuan^1,2, ZHANG Hong¹, YUAN Xiao-Yan^1*

1. School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China;
2. Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Third Military Medical University, Chongqing 400038, China

Received:2010-07-28 Revised:2010-09-12 Online:2011-06-10 Published:2011-05-10
Contact: YUAN Xiao-Yan E-mail:yuanxy@tju.edu.cn
Supported by:
国家自然科学基金(批准号: 50573055)和天津市应用基础及前沿技术研究计划(批准号: 09JCZDJC18600)资助.

Abstract

Abstract: Core/shell ultrafine fibers, with dextran (DEX) and poly(ethylene glycol)-b- poly(L-lactide-co-ε-caprolactone) (PELCL) as the core and shell, respectively, were prepared by coaxial electrospinning. Double-layered ultrafine fibrous tubes of the coaxial-electrospun DEX/PELCL fibers were constructed for application as artificial blood vessel by loading vascular endothelial growth factor (VEGF) and platelet derived growth factor-bb (PDGF-bb), respectively in the fiber core. The in vitro releasing results of 4 w indicated that initial burst release occurred for both VEGF and PDGF-bb. The in vivo implantation in abdomen aorta of a rat model showed that the double-layered fibrous tubes loading VEGF and PDGF-bb could be potential used as artificial blood vessels.

Key words: Coaxial electrospinning, Ultrafine fiber, Controlled release, Growth factor, Artificial blood vessel

TrendMD:

CAO Wen-Xuan, ZHANG Hong, YUAN Xiao-Yan*. Ultrafine Fibrous Membranes by Coaxial Electrospinning for Artificial Blood Vessel[J]. Chem. J. Chinese Universities, 2011, 32(6): 1396.

[1]	CHEN Hongda, ZHANG Hua, WANG Zhenxin. Development of Small Animals in vivo Fluorescence-photothermal Dual Mode Imaging System [J]. Chem. J. Chinese Universities, 2021, 42(3): 725.
[2]	ZHAO Yu, CAO Wanqing, LIU Yang. Recent Advances in Polymeric Nano-sized Carrier Systems ^† [J]. Chem. J. Chinese Universities, 2020, 41(5): 909.
[3]	LI Ming,CUI Xiaoqian,WANG Xuan,LI Zaijun. Synthesis of Amphiphilic Graphene Quantum Dots and Their Sustained Release Effect on L-Menthol ^† [J]. Chem. J. Chinese Universities, 2020, 41(2): 324.
[4]	REN Jing, WANG Shugang, LI Yanchun, YANG Qingbiao, SONG Yan, LI Yaoxian. Preparation of AOPAN@PAN Coaxial Nanofiber Membrane and It’s Adsorption Property^† [J]. Chem. J. Chinese Universities, 2018, 39(4): 825.
[5]	ZHAO Qi, HE Wanying, DUAN Lijie, ZHANG Yu, YU Shuangjiang, GAO Guanghui. Fabrication and Characterization of Injectable Polysaccharide-polypeptide Hydrogel Based on Schiff’s Base^† [J]. Chem. J. Chinese Universities, 2016, 37(9): 1750.
[6]	WANG Juan, ZHOU Bing, WANG Xinxin, WU Xiujuan, LI Ting, ZHANG Wenke, LIU Kangding. Preparation of Fe₃O₄ Nanoparticles and Lentiviral Vector Infected EPCs for the Improvement of Angiogenesis and MRI Tracing^† [J]. Chem. J. Chinese Universities, 2016, 37(6): 1148.
[7]	ZHANG Huilan, YI Bingcheng, WANG Xianliu, LI Biyun, YU Zhepao, LOU Xiangxin, ZHANG Yanzhong. Highly Aligned Ultrafine Fibers of Graphene/Poly(L-lactic acid)(Gr/PLLA) Composite for the Construction of Nerve Conduit^† [J]. Chem. J. Chinese Universities, 2016, 37(5): 972.
[8]	YANG Junxing, WANG Qi, WANG Yuanyuan, HAN Shu, YAO Jiawei, SHAO Siqi, WANG Jinglong, LIU Zhihui, GUO Yupeng. Preparation and in vitro Release of Multilayer Alginate Chitosan Microspheres Loading VEGF and Vancomycin^† [J]. Chem. J. Chinese Universities, 2015, 36(5): 1025.
[9]	LIU Haibin, LÜ Ping, PAN Ningning, AI Limei, LIU Yongxiang. Synthesis and In vitro Anticancer Activity of Novel Quinazoline Derivatives Containing Thiosemicarbazone Structure^† [J]. Chem. J. Chinese Universities, 2014, 35(5): 981.
[10]	YU Haiyang, TANG Zhaohui, SONG Wantong, DENG Mingxiao, CHEN Xuesi. Current Status and Future Prospects of Polymeric Nanocarrier for Tumor Targeting^† [J]. Chem. J. Chinese Universities, 2014, 35(5): 903.
[11]	KANG Congmin, ZHAO Xuhao, YU Yuqi, LÜ Yingtao. De novo Design of Indole Derivatives as VEGFR-2 Tyrosine Kinase Inhibitors^† [J]. Chem. J. Chinese Universities, 2014, 35(3): 550.
[12]	SUN Lili, WANG Haoran, XU Yiming, FEI Dan, FU Tingting, GUAN Guofang. Synthesis and Characterization of a Melttin Expressing Recombinant Antibody Targeting Human Laryngeal Cancer^† [J]. Chem. J. Chinese Universities, 2014, 35(12): 2551.
[13]	MA Xiu-Ming, PANG Xiu-Jiang, QUAN Zhen-Lan, HOU Wan-Guo. Synthesis and Characterization of 10-Hydroxyl Camptothecin-Sebacate-LDH Nanohybrid [J]. Chem. J. Chinese Universities, 2013, 34(4): 913.
[14]	ZHAO Chun-Ling, HUA Mei, ZHAO Xiao-Hui, HUANG Liang-Liang, FENG Ya-Juan, NIU Si-Peng, FU Xue-Wen, YUAN Cong, YANG Yun-Hui. Preparation of Label-free Aptasensor for the Detection of Platelet-derived Growth Factor [J]. Chem. J. Chinese Universities, 2013, 34(1): 61.
[15]	SUN Shu-Fen, LI Nan-Nan, LIU Min, LIU Yi-Cong, ZHANG Ying-Chao, ZHOU Yan-Min. Preparation and Bioactivities of Electrospun PBS Nanofiber Membrane and Hybrid PBS Nanofiber Membrane of Sustained Release Growth Factors in Platelet [J]. Chem. J. Chinese Universities, 2012, 33(12): 2827.

Ultrafine Fibrous Membranes by Coaxial Electrospinning for Artificial Blood Vessel

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments