Abstract: Abstract Phthalocyanine conjugation with galactose was synthesized as Near-infrared fluorescent probes. In vivo fluorescence imaging effect and organ distribution of probe was conducted with nude mice bearing liver cancer as model , result shows that galactose modified phthalocyanine have obvious near-infrared imaging effect in vivo and a certain tumor targeting ability. So the near infrared optical probe can be potentially applied in the diagnosis of cancer in future.

Key words: Near infrared fluorescence probe, Galactose, Phthalocyanines, Tumor imaging