Interaction Between Dicationic Carbazole Derivatives and Nucleic Acid by Spectrum

Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (9): 1860.

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Interaction Between Dicationic Carbazole Derivatives and Nucleic Acid by Spectrum

ZHANG Yuan-Hong¹, SUN Yu-Ming², LIU Xin¹, ZHAO Ning¹, YU Xiao-Qiang^1*, HUANG Bai-Biao^1*

1. State Key Laboratory of Crystal Materials,
2. Optics Department, Shandong University, Jinan 250100, China

Received:2010-06-07 Online:2010-09-10 Published:2010-09-10
Contact: YU Xiao-Qiang. E-mail: yuxq@sdu.edu.cn; HUANG Bai-Biao. E-mail: bbhuang@sdu.edu.cn
Supported by:
国家自然科学基金(批准号: 50673053, NSFC/RGC50218001, 50173015, 20973102)资助.

Abstract

Abstract: In this paper, 3,6-bis(1-hydroxyethyl-4-vinylpyridinium) carbazole diiodide(3,6-BHVC), a novel dicationic carbazole derivative, was synthesized and characte-rized. Using electronic absorption spectra, circle dichroism spectra and one- and two-photon emission spectra, the binding modes between 3,6-BHVC and DNA were studied. All spectral results show that 3,6-BHVC intercalates into DNA base pairs at lower ratio of [phosphate]/[3,6-BHVC] and binds in DNA groove at higher ratio. This indicates that carbazole derivative can act as a primary structure to explore two-photon DNA probes with high binding affinity.

Key words: Dicationic carbazole derivative, Two-photon fluorescent DNA probe, Binding mode

TrendMD:

ZHANG Yuan-Hong, SUN Yu-Ming, LIU Xin, ZHAO Ning, YU Xiao-Qiang*, HUANG Bai-Biao. Interaction Between Dicationic Carbazole Derivatives and Nucleic Acid by Spectrum[J]. Chem. J. Chinese Universities, 2010, 31(9): 1860.

References

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Interaction Between Dicationic Carbazole Derivatives and Nucleic Acid by Spectrum

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