Proteomic Analysis of Olfactory Memory Related Proteins in Mice

Abstract

Abstract: To investigate olfactory memory related proteins, olfactory bulb proteins from C57BL/6J mice after olfactory discrimination task were extracted and subjected to 2D gel electrophoresis. Protein quantification was performed and the differentially expressed spots were identified using mass spectrometry and Swiss-Prot database searching with MASCOT software. Olfactory bulb proteins from C57BL/6J mice after olfactory discrimination task were significantly different. Expression levels of 2 spots upregulated significantly; expression levels of 3 spots downregulated significantly. Functions of these identified proteins were involved in neurogenesis, signal transduction, cytoskeleton and nucleotide acid metabolism. These proteins improved insights into the olfactory memory mechanism and provided new targets for the study and treatment of cognitive diseases.

Key words: Olfactory recognition memory, Olfactory bulb, Proteomics, Mass spectrometry

TrendMD:

ZHENG Jun-Fang, HUA Lin, ZHANG Qiu-Xia, LI De-Long, HE Jun-Qi*. Proteomic Analysis of Olfactory Memory Related Proteins in Mice[J]. Chem. J. Chinese Universities, 2010, 31(8): 1535.

References

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