An Integrated Microfluidic Chip for Drug-metabolism

Chem. J. Chinese Universities

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An Integrated Microfluidic Chip for Drug-metabolism

ZHANG Guo-Hao, MA Bo, QIN Jian-Hua, LIN Bing-Cheng*

Dalian Institute of Chemical and Physics, Chinese Academy of Sciences, Dalian 116023, China

Received:2008-02-01 Revised:1900-01-01 Online:2008-07-10 Published:2008-07-10
Contact: LIN Bing-Cheng

Abstract

Abstract: In this paper, we report an integrated microfluidic chip for drug-metabolism. The chip contains three layers: the top PDMS cover, the middle quartz slide with microchannels and microwells, the bottom PDMS layer for cell culture. Microsomes isolated from human liver were encapsulated in microwells by sol-gel method.Using this design, the determination of the metabolites and drug cytotoxicity assessment can be carried out within a single microfluidic device, providing an alternative technique for the high-throughput parallel drug screening and drug interactions in the metabolic pathways.

Key words: Microfluidic chip, Drug-metabolism, Microsome, Sol-gel

CLC Number:

O657

TrendMD:

ZHANG Guo-Hao, MA Bo, QIN Jian-Hua, LIN Bing-Cheng*. An Integrated Microfluidic Chip for Drug-metabolism[J]. Chem. J. Chinese Universities, doi: .

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An Integrated Microfluidic Chip for Drug-metabolism

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