Cytotoxic Constituents from Marine Actinomycete Streptomyces sp. 124092

Chem. J. Chinese Universities

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Cytotoxic Constituents from Marine Actinomycete Streptomyces sp. 124092

XIE Xiu-Chao^1,2, MEI Wen-Li¹, ZENG Yan-Bo¹, LIN Hai-Peng¹, ZHUANG Ling¹, DAI Hao-Fu^1*, HONG Kui^1*

1. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;
2. Shanxi Key Laboratory of Resource Biology, Shanxi University of Technology, Hanzhong 723001, China

Received:2008-03-03 Revised:1900-01-01 Online:2008-11-10 Published:2008-11-10
Contact: DAI Hao-Fu, HONG Kui

Abstract

Abstract: To study the cytotoxic constituents from marine actinomycete Streptomyces sp.(124092) of rhizosphere soil of mangrove plant Heritiera littoralis, five compounds were isolated by column chromatography from the fermentation broth of marine actinomycete Streptomyces sp.(124092). Their structures were elucidated as p-tolyl 3-aminopropanoate(1), 6-amino-3-(4-hydroxybenzyl)-1,4-diazonane-2,5-dione(2), n-butyl mannoside(3), daidzein(4), and indole-β-carboxylic acid(5), by MS, NMR, ¹H-¹H COSY, HMQC, and HMBC spectra. Among them, compounds 1 and 2 are new compounds. Cytotoxic bioassay results show that compounds 1—4 possess inhibitory effects on human hepatoma SMMC-7721 cell line in vitro.

Key words: Marine actinomycete, Streptomyces sp., Cytotoxicity, Isolation and purification

CLC Number:

O629

TrendMD:

XIE Xiu-Chao^1,2, MEI Wen-Li¹, ZENG Yan-Bo¹, LIN Hai-Peng¹, ZHUANG Ling¹, DAI Hao-Fu^1*, HONG Kui^1*. Cytotoxic Constituents from Marine Actinomycete Streptomyces sp. 124092[J]. Chem. J. Chinese Universities, doi: .

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Cytotoxic Constituents from Marine Actinomycete Streptomyces sp. 124092

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