Synthesis and pH and Temperature Sensitive Properties of OSM1-PCLA-PEG-PCLA-OSM1 Block Copolymers

Chem. J. Chinese Universities

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Synthesis and pH and Temperature Sensitive Properties of OSM₁-PCLA-PEG-PCLA-OSM₁ Block Copolymers

HAO Tang-Na, QIAO Ming-Xi, GU Jian-Chun, LI Zhen, HU Hai-Yang, ZHAO Xiu-Li, CHEN Da-Wei^*

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2007-12-18 Revised:1900-01-01 Online:2008-10-10 Published:2008-10-10
Contact: CHEN Da-Wei

Abstract

Abstract: A new kind of biodegradable pH and temperature sensitive block copolymers were synthesized by ring-opening and conventional free radical polymerizations. The chemical structure of OSM₁-PCLA-PEG-PCLA-OSM₁ block copolymers was characterized via FTIR and ¹H NMR. Critical micelle concentration and particle size distribution were studied by fluorospectrophotometer and laser size detector to verify the copolymers micelle formation. The results of sol-gel transition show that the block copolymers solution possesses both pH and temperature sensitive properties. Different block copolymer solutions can form a stable gel obviously at certain temperature. OSM₁-PCLA-PEG-PCLA-OSM₁ block copolymers could be potential intelligent polymers materials for drug delivery system because of its pH and temperature sensitive properties.

Key words: pH sensitivity, Temperature sensitivity, Biodegradation, Block copolymer, Hydrogels

CLC Number:

O631

TrendMD:

HAO Tang-Na, QIAO Ming-Xi, GU Jian-Chun, LI Zhen, HU Hai-Yang, ZHAO Xiu-Li, CHEN Da-Wei^*. Synthesis and pH and Temperature Sensitive Properties of OSM₁-PCLA-PEG-PCLA-OSM₁ Block Copolymers[J]. Chem. J. Chinese Universities, doi: .

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Synthesis and pH and Temperature Sensitive Properties of OSM₁-PCLA-PEG-PCLA-OSM₁ Block Copolymers

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