Abstract: Laminine(4) is a kind of non-protein amino acids in the kelp, which can prevent and cure hypertension. Because of its trace amount in the nature, it was always prepared by using bio-mimetic synthesis methods. And none or few of the synthetic methods of compound 4 were reported so far. In this article, with lysine(1) as the starting material, compound 4 was prepared with bio-mimetic synthesis method, with a yield of 37.6% and a purity of 97.2%. The structure of compound 4 was determined via HPLC, IR, MS, ¹H NMR, ¹³C NMR and element analysis, and some of its physical and chemical properties were also studied. The results show that compound 4 is white crystalloid and has no smell, the quasi-molecular ion peak of compound 4 is m/z 207.1, and chemical shift δ 3.63(s, 9H), the features at 2945, 2863 and 1480 cm^-1 in IR spectrum all show that ε-amino group of compound 4 is fully alkylated. This method could get pure laminine with simple operations, and it could be considered as a green technology with great industrial profits and notable ecological values.

Key words: L-Lysine, Laminine, Bio-mimetic synthesis method, Green chemistry