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Chem. J. Chinese Universities ›› 2012, Vol. 33 ›› Issue (07): 1456.doi: 10.3969/j.issn.0251-0790.2012.07.016

• Organic Chemistry • Previous Articles     Next Articles

Synthesis of Poly(ethylene glycol)-poly(L-lysine) Diblock Copolymer Incorporating Tetra-(p-sulfoazophenyl-4-aminosulfonyl)phthalocyanine Chloride Aluminum(Ⅲ) Polyion Nanoparticles and Its in vitro Photodynamic Therapy Efficacy

MA Dong-Dong1, LIN Ping-Ping1, CHEN Li-Li1, WANG Yu-Hua2, HE Dan-Dan1, CHEN Wan-Ling1, ZHANG Tian-Tian1, CHEN Kui-Zhi1, PENG Yi-Ru1,2   

  1. 1. College of Chemistry and Materials Science, Fujian Provincial Key Laboratory of Polymer Materials,Fujian Normal University, Fuzhou 350007, China;
    2. Key Lab of Optoelectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou 350007, China
  • Received:2012-01-04 Online:2012-07-10 Published:2012-07-10

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Abstract: A novel tetra-(p-sulfoazophenyl-4-aminosulfonyl)phthalocyanine aluminum(Ⅲ) chloride(S-AlPc) was synthesized and characterized by elemental analysis, IR, 1H NMR and ESI-MS. Polyion nanoparticles(S-AlPc/PbP) loaded with S-AlPc were formed through electrostatic self-assemble by negatively charged sulfonate groups with positively charged PLL of the poly(ethylene glycol)-poly(L-lysine) amphiphilic diblock copolymer(PEG-b-PLL). The diameter of S-AlPc/PbP was about 10-20 nm. The photophysical properties of S-AlPc/PbP and S-AlPc were compared by UV-Vis, steady-state and time-resolved fluorescence spectroscopy. The time-depended uptake amounts of S-AlPc and S-AlPc/PbP in the human umbilical cord blood endothelial cells(HUVEC) were studied. The uptake amounts of S-AlPc/PbP by HUVEC reached maximum about one hour earlier than that of the S-AlPc. The phototoxicity of S-AlPc and S-AlPc/PbP was evaluated by MTT method. The inhibition rate of S-AlPc/PbP was also significantly increased. These results obviously indicated that S-AlPc/PbP is a potential 3rd generation photosensitizer for photodynamic therapy.

Key words: Phthalocyanine aluminium, Polyion nanoparticles, Photodynamic therapy efficacy, Poly(ethylene glycol)-poly(L-lysine) diblock copolymer, Photosensitizer

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