Chem. J. Chinese Universities

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Synthesis and in vivo Antiinflammatory Activity of Novel E-1-substituted Phenyl-3-(3'-substituted indolyl)-2-propenones

GUO Xiao-He1,2, CHENG Sen-Xiang3, CHENG Gui-Fang4, XIE Jing-Xi3, CHANG Jun-Biao1,2   

    1. Department of Chemistry, University of Science and Technology of China, Hefei 230026, China;
    2. Xinxiang Medical University, Xinxiang 453003, China;
    3. Henan Key Laboratory of Fine Chemicals, Zhengzhou 450002, China;
    4. Institute of Materia Medica, Chinese Academy of Medical Sciences and Perking Union Medical College, Beijing 100051, China
  • Received:2005-09-05 Revised:1900-01-01 Online:2006-09-10 Published:2006-09-10
  • Contact: CHANG Jun-Biao

Abstract: A series of novel propenylone compounds 3a—3p were designed and synthesized. The title compounds were characterized by 1H NMR, IR and LC/MS. Antiinflammatory activity of compounds 3a—3i were evaluated with a in vivo model of mice ear acute inflammation edema induced by croton oil. Compounds 3d, 3f, 3g exhibited a potent antiinflammatory activity and their inhibition ratios were 19.5%, 27.6% and 16.1%, respectively.

Key words: Synthesis, Anti-inflammatory activity, Propenone

CLC Number: 

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