Heavy-atom Effect of Corrole Photosensitizer for Photodynamic Therapy

Chem. J. Chinese Universities

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Heavy-atom Effect of Corrole Photosensitizer for Photodynamic Therapy

LIU Hai-Yang^1,2*; GUO Ping-Ye¹; KONG Pak-Wing²; YING Xiao³; LIAO Shi-Jun¹; MAK Nai-Ki⁴; CHANG Chi-Kwong^2*

1. Department of Chemistry, South China University of Technology,
Guangzhou 510641, China;
2. Department of Chemistry, Hong Kong University of Science & Technology,
Hong Kong, China;
3. Department of Applied Physics, South China University of Technology,
Guangzhou 510641, China;
4. Department of Biology, Hong Kong Baptist University, Hong Kong, China

Received:2006-02-13 Revised:1900-01-01 Online:2006-07-10 Published:2006-07-10
Contact: LIU Hai-Yang; ZHANG Qi-Guang

Abstract

Abstract: 10-(2-Hydroxylphenyl)-5,15-bis(pentafluorophenyl) corrole was found to have a remarkable photocytotoxicity on nasopharyngeal carcinoma(NPC) cell line(Chang C. K. et al., Proc SPIE, 2006, Vol. 6139, p268). To explore the heavy-atom effect on corrole photosensitizer, an exact analogue of corole 1 with the modification of two heavy iodine atoms on its 10-phenyl group, 10-(2-hydroxyl-3,5-diiodophenyl)-5,15-bis(pentafluorophenyl)corrole, were synthesized.

Key words:

Corrole, Photosensitizer, Nasopharyngeal carcinoma, Photodynamic therapy, Heavy-atom effect

CLC Number:

O644.12

TrendMD:

LIU Hai-Yang^1,2*; GUO Ping-Ye¹; KONG Pak-Wing²; YING Xiao³; LIAO Shi-Jun¹; MAK Nai-Ki⁴; CHANG Chi-Kwong^2*. Heavy-atom Effect of Corrole Photosensitizer for Photodynamic Therapy[J]. Chem. J. Chinese Universities, doi: .

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Heavy-atom Effect of Corrole Photosensitizer for Photodynamic Therapy

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