Studies on Interaction of New Medicine of QuinoloneClass with HSA and BSA by Using Fluorescence Enhancement and Fluorescence Quenching Theory

Chem. J. Chinese Universities ›› 2006, Vol. 27 ›› Issue (4): 687.

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Studies on Interaction of New Medicine of QuinoloneClass with HSA and BSA by Using Fluorescence Enhancement and Fluorescence Quenching Theory

YANG Man-Man, XI Xiao-Li, YANG Pin*

Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of
Molecular Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China

Received:2005-05-24 Online:2006-04-10 Published:2006-04-10
Contact: YANG Pin,E-mail: yangpin@sxu.edu.cn

Abstract

Abstract:

By using the two theoriesfluorescence enhancement and fluorescence quenching, we studied and compared the inter action of four kinds of Quinolone-class-medicines with HSA and BSA, then analysed deeply the binding speciality of medicine and albumin and usual characterization constants: dissociation constant, quenching constant, quenching efficiency, energytransfer efficiency, the distance between donor and accepter. About binding type of albumin with medicine, through the quenching experiment result of the four kinds of medicines with HSA and BSA, we found that this quenching action type caused by the binding of donor between acceptor was not determined by the oneselfbiomacromolecule BSA, but together determined by the molecular structure of BSA and medicine, donor and acceptor, and their match with each other.

Key words: Fluorescence enhancement and quenching; HSA; BSA; Quinolone-class-medicine

CLC Number:

O644
O657

TrendMD:

YANG Man-Man, XI Xiao-Li, YANG Pin. Studies on Interaction of New Medicine of QuinoloneClass with HSA and BSA by Using Fluorescence Enhancement and Fluorescence Quenching Theory[J]. Chem. J. Chinese Universities, 2006, 27(4): 687.

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Studies on Interaction of New Medicine of QuinoloneClass with HSA and BSA by Using Fluorescence Enhancement and Fluorescence Quenching Theory

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