Research of 3-(4-Aminophenyl)-indolizine Derivatives asFluorescent Probes for Protons

Chem. J. Chinese Universities ›› 2006, Vol. 27 ›› Issue (4): 651.

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Research of 3-(4-Aminophenyl)-indolizine Derivatives asFluorescent Probes for Protons

SHEN Yong-Miao ¹, WANG Bing-Xiang ^1,3*, FENG Yu-Ying ², SHEN Zhu-Ying ¹ , SHEN Jian ^1,3,4, LI Cun¹, HU Hong-Wen⁴

1. College of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097, China;
2. Analysis and Test Center, Nanjing Normal University, Nanjing 210097, China;
3. Jiangsu Research Center of Biomedical Functional Materials Engineering, Nanjing 210097, China;
4. College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China

Received:2005-01-27 Online:2006-04-10 Published:2006-04-10
Contact: WANG Bing-Xiang, E-mail: wangbingxiang@njnu.edu.cn

Abstract

Abstract:

Fluorescent molecular probes and switches system plays an important part in molecular recognition. The study on fluorescent probes and switches of proton guest has been developing rapidly in recent years. The modular structure of fluorspaceramine is pointed out to be important according to the principle of photoinduced electron transfer(PET). Three derivatives of 3-(4-aminophenyl)-indolizine were synthesized for the design of fluorescent molecular probes for pH. The fluorescence spectra and fluorescence quantum yields of the compounds were examined. The present study suggests that 3-(4-aminophenyl)-indolizine derivatives 3a and 3b were appropriate to measure pH values in the range 2.1—4.2 by a ratiometric method that relies on fluorescence emission. It suggested that derivatives of 3-(4-aminophenyl)-indolizine could find useful applications as intracellular pH meters.

Key words: Indolizine; Proton probe; Fluorescent switch

CLC Number:

O629

TrendMD:

SHEN Yong-Miao, WANG Bing-Xiang, FENG Yu-Ying, SHEN Zhu-Ying, SHEN Jian. Research of 3-(4-Aminophenyl)-indolizine Derivatives asFluorescent Probes for Protons[J]. Chem. J. Chinese Universities, 2006, 27(4): 651.

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Research of 3-(4-Aminophenyl)-indolizine Derivatives asFluorescent Probes for Protons

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