Synthesis of Phenylenedimethylene Bis(guanidiniums) Derivatives

Abstract

Abstract:

Naturally occurring and synthetic compounds containing guanidine display a wide range of biological activities and are used as a receptor for organic anions. This paper reports the synthesis of phenylenedimethy-lene diamines and bis(guanidiniums) derivatives. The phenylenedimethylene diamine derivatives were prepared by the reaction of phenylenedimethylene dichloride with sodium diformamide and then hydrolyzing with hydrochloric acid/ethanol solution. The diamines were respectively treated with S-methylisothiourea sulfate to give the corresponding phenylenedimethylene bis(guanidiniums) sulfate,and then they were converted to the corresponding chlorides by ion-exchange process. ¹H NMR spectra and ESIMS data indicate that they display a stronger interaction with organic anions.

Key words: Guanidine; Bis(guanidiums); Diamine; Synthesis

CLC Number:

O626

TrendMD:

SONG Wei, LU Xiao-Feng, LU Guo-Yuan. Synthesis of Phenylenedimethylene Bis(guanidiniums) Derivatives[J]. Chem. J. Chinese Universities, 2006, 27(3): 460.

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Synthesis of Phenylenedimethylene Bis(guanidiniums) Derivatives

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