Synthesis and Biological Activity of 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-oxoacetohydrazone Derivatives

Chem. J. Chinese Universities ›› 2006, Vol. 27 ›› Issue (3): 454.

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Synthesis and Biological Activity of 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-oxoacetohydrazone Derivatives

CHEN Qiong¹, LONG De-Qing^1,2, CHENG Jing ¹, LI Jing¹, LIU Zu-Ming¹, YANG Guang-Fu ^1*

1. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education; College of Chemistry, Central China Normal University, Wuhan 430079, China;
2. Department of Chemistry, Yunyang Teacher′s College, Danjiangkou 442700, China

Received:2005-03-29 Online:2006-03-10 Published:2006-03-10
Contact: YANG Guang-Fu, E-mail: gfyang@mail.ccnu.edu.cn

Abstract

Abstract:

Fifteen novel 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-oxoacetohydrazone derivatives and ten novel (R)-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-oxo(α-methyl)acetohydrazone derivatives were designed and synthesized by using 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-|2-methylthioether as the starting material. All synthesized compounds were confirmed by elemental analysis, MS and¹H NMR. The preliminary bioassay indicates that some of them display good herbicidal and fungicidal activities. Those compounds with chiral center display better bioactivities.

Key words: 1,2,4-Triazolo[1,5-a-]pyrimidine; Acetohydrazone; Biological activity; Chiral center

CLC Number:

O626

TrendMD:

CHEN Qiong, LONG De-Qing, CHENG Jing, LI Jing, LIU Zu-Meng, YANG Guang-Fu. Synthesis and Biological Activity of 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-oxoacetohydrazone Derivatives[J]. Chem. J. Chinese Universities, 2006, 27(3): 454.

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Synthesis and Biological Activity of 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-oxoacetohydrazone Derivatives

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