Chem. J. Chinese Universities ›› 2006, Vol. 27 ›› Issue (3): 454.

• Articles • Previous Articles     Next Articles

Synthesis and Biological Activity of 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-oxoacetohydrazone Derivatives

CHEN Qiong1,   LONG De-Qing1,2,   CHENG Jing 1,  LI Jing1,   LIU Zu-Ming1,   YANG Guang-Fu 1*   

  1. 1. Key Laboratory of Pesticide & Chemical Biology,  Ministry of Education; College of Chemistry,  Central China Normal University,  Wuhan  430079, China;
    2. Department of Chemistry,  Yunyang Teacher′s College,  Danjiangkou  442700,   China
  • Received:2005-03-29 Online:2006-03-10 Published:2006-03-10
  • Contact: YANG Guang-Fu, E-mail: gfyang@mail.ccnu.edu.cn

Abstract:

Fifteen novel 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-oxoacetohydrazone derivatives and ten novel (R)-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-oxo(α-methyl)acetohydrazone derivatives were designed and synthesized by using 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-|2-methylthioether as the starting material. All synthesized compounds were confirmed by elemental analysis,  MS and 1H NMR. The preliminary bioassay indicates that some of them display good herbicidal and fungicidal activities. Those compounds with chiral center display better bioactivities.

Key words: 1,2,4-Triazolo[1,5-a-]pyrimidine; Acetohydrazone;  Biological activity; Chiral center

CLC Number: 

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