Synthesis and Bioactivity of N-(2-Alkoxy-2-substituted phenyl-ethyl)phenyl Amide

doi:10.3969/j.issn.0251-0790.2012.07.021

Abstract

Abstract: Mandipropanid is the first mandelamlamide fungicide on the market. A series of novel N-(2-alkoxy-2-substituted phenyl-ethyl) phenyl amide(8) was designed according to exchange the position of NH and C=O from mandipropamid. The target compounds were synthesized from benzene acetic acid and acetophenone(3) by bromination, amination and so on. Their structures were characterized by ¹H NMR, elemental analysis or high resolution mass spectra(HRMS). The results of the preliminary biological activity tests show that some of them like compound 8k exhibit good anti-fungal activities against Pseudoperonospora cubenis at 100 μg/mL. The study also finds that these compounds have a certain control on the effect of Tetranychus cinnabarinus.

Key words: Anti-fungal activity, Insecticide activity, 2-Amino-1-phenylethanol, Phenylethyl amide

CLC Number:

O626

TrendMD:

YAO Hong-Wei, CUI Can, LI Yong-Qiang, WANG Li-Zhong, LI Zheng-Ming, ZHAO Wei-Guang. Synthesis and Bioactivity of N-(2-Alkoxy-2-substituted phenyl-ethyl)phenyl Amide[J]. Chem. J. Chinese Universities, 2012, 33(07): 1481.

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Synthesis and Bioactivity of N-(2-Alkoxy-2-substituted phenyl-ethyl)phenyl Amide

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