Application of Chiral Spiro Monophosphorus Ligands in Rhodium-catalyzed Asymmetric Hydroformylation

Chem. J. Chinese Universities

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Application of Chiral Spiro Monophosphorus Ligands in Rhodium-catalyzed Asymmetric Hydroformylation

FAN Bao-Min¹, XIE Jian-Hua², ZHOU Zhang-Tao², ZHANG Qi², TU Yong-Qiang¹, ZHOU Qi-Lin²

1. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China;
2. State Key Laboratory of Elementoorganic Chemistry, Institute of Elementoorganic Chemistry, Nankai University, Tianjin 300071, China

Received:2005-09-27 Revised:1900-01-01 Online:2006-10-10 Published:2006-10-10

Abstract

Abstract: The application of three types of chiral spiro monophosphorus ligands in rhodium-catalyzed asymmetric hydroformylation was investigated. The chiral spiro phosphoramidite ligands(SIPHOS) were found to be efficient in this reaction, and the alkyl groups on the amino moiety of SIPHOS ligands played a critical role in the control of regio-selectivity and enantioselectivity of the reaction, with i-Pr being the best choice. Under the optimized reaction conditions, styrene and its derivatives could successfully react as substrates in excellent yields and regio-selectivities, and modest level of enantioselctivities.

Key words: Hydroformylation, Asymmetric catalysis, Monophosphorus ligand, Rhodium

CLC Number:

O62
O643

TrendMD:

FAN Bao-Min¹, XIE Jian-Hua², ZHOU Zhang-Tao², ZHANG Qi², TU Yong-Qiang¹, ZHOU Qi-Lin². Application of Chiral Spiro Monophosphorus Ligands in Rhodium-catalyzed Asymmetric Hydroformylation[J]. Chem. J. Chinese Universities, doi: .

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Application of Chiral Spiro Monophosphorus Ligands in Rhodium-catalyzed Asymmetric Hydroformylation

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