Synthesis of Amphiphilic Diblock Copolymer Poly(L-alanine)-b-poly(hydroxyethyl glutamine) and Its Self-assembly in Water

Abstract

Abstract: Two kinds of amino acid N-carboxyanhydrides γ-benzyl-glutamate N-carboxyanhydride(GluB-NCA), and L-alanine N-carboxyanhydride(Ala-NCA) were synthesized according to phosgene method(Fuchs-Farthing method). Poly(L-alanine)-block-poly(γ-benzyl-glutamate)(PLA-b-PBLG) AB diblock copolypeptide was synthesized by ring opening polymerization of Ala-NCA and GluB-NCA, with triethylamine as the initiator. The poly(L-alanine)-b-poly(hydroxyethyl glutamine)(PLA-b-PHEGA) diblock copolypeptide was obtained by reacting the PLA-b-PBLG diblock copolypeptide with ethanolamine to improve the hydrophilicity of PBLG block. The structure of the product was characterized by means of FTIR and ¹HNMR. The aggregation morphologies of the PLA-b-PHEGA diblock copolypeptide in aqueous solution were observed by TEM. It was found that the diblock copolypeptide could be self-assembled to form vesicles in water.

Key words: Poly(γ-benzyl-glutamate), Poly(L-alanine), Block copolymer, Self-assembly

CLC Number:

O631

TrendMD:

LI Li-Ying, SUN Ping-Chuan, YAO Yang, CHEN Tie-Hong, LI Bao-Hui, JIN Qing-Hua, DING Da-Tong . Synthesis of Amphiphilic Diblock Copolymer Poly(L-alanine)-b-poly(hydroxyethyl glutamine) and Its Self-assembly in Water[J]. Chem. J. Chinese Universities, 2005, 26(8): 1544.

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Synthesis of Amphiphilic Diblock Copolymer Poly(L-alanine)-b-poly(hydroxyethyl glutamine) and Its Self-assembly in Water

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