Synthesis of Chlorin-enediyne Dyads Fused with Heterocyclic Ring by Palladium-catalyzed Coupling Reaction

Chem. J. Chinese Universities ›› 2005, Vol. 26 ›› Issue (8): 1474.

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Synthesis of Chlorin-enediyne Dyads Fused with Heterocyclic Ring by Palladium-catalyzed Coupling Reaction

YIN Jun-Gang^1,2, WANG Jin-Jun², SHIM Young-Key³

1. Collgeg of Chemistry and Chemical Engineering, Lanzhou 730000, China;
2. Department of Applied Chemistry, Yantai University, Yantai 264005, China;
3. School of Nano Engineering, Inji University, Pusan, Korea

Received:2004-08-26 Online:2005-08-10 Published:2005-08-10

Abstract

Abstract: The terminal alkyne was constructed in chlorin chromophore by Grignard reaction and oxidation to give chlorin 2 and 3, respectively. After deprotection the diketo chlorin 4 was obtained which was readily converted to the Zn-complex 5. Chlorin-enediyne dyads 6 fused with heterocyclic ring was synthesized by a palladium-catalyzed coupling reaction with 2-(1-hexynyl)-3-chlorothiophene.

Key words: Coupling reaction, Pyropheophorbide, Chlorin-enediyne dyads, Photodynamic therapy

CLC Number:

O622

TrendMD:

YIN Jun-Gang, WANG Jin-Jun, SHIM Young-Key . Synthesis of Chlorin-enediyne Dyads Fused with Heterocyclic Ring by Palladium-catalyzed Coupling Reaction[J]. Chem. J. Chinese Universities, 2005, 26(8): 1474.

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Synthesis of Chlorin-enediyne Dyads Fused with Heterocyclic Ring by Palladium-catalyzed Coupling Reaction

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