Synthesis of Chiral Stationary Phases via Bonding β-cyclodextrin with α-Schiff Base and Chromatographic Performance

Abstract

Abstract: Two chiral stationary phases(BCDs and YBCDs) were prepared by bonding β-cyclodextrin derivative with α-Schiff base group from β-cyclodextrin monoaldehyde to the sillica gel via 3-glyci-dyloxypropyltrimethoxysilane as a coupling agent. Using acetonitrile-TEAA as mobile phase, good enantiomeric resolutions were obtained for DL-aminoacide on BCDs and YBCDs, including Leucine, Threonine and Valine. It is also observed that the higher separation factor of threonine was at pH {7.11} for both of the column, and the optimal column temperatures of Leucine appeared at 30 ℃ or 40 ℃, respectively for YBCDs and BCDs.

Key words: Schiff base, β-Cyclodextrin, HPLC

CLC Number:

O658

TrendMD:

FANG Min, ZHOU Zhi-Ming, LUO Ai-Qin . Synthesis of Chiral Stationary Phases via Bonding β-cyclodextrin with α-Schiff Base and Chromatographic Performance[J]. Chem. J. Chinese Universities, 2005, 26(8): 1443.

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Synthesis of Chiral Stationary Phases via Bonding β-cyclodextrin with α-Schiff Base and Chromatographic Performance

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