Synthesis and Crystal Structure of the Fused Quinazoline Spiro-heterocyclic Compounds

Abstract

Abstract: The new fused quinazoline spiro-heterocyclic compounds were synthesized by combining the fused thiazolidone and quinazoline structure with spiro-heterocyclic structure for the purpose to get novel bio-active compounds. Dipolar azomethine ylides reacted with dipolarphile 2-arylmethylene-9-benzylidene-5-phenyl-6,7,8,9-tetrahydro-5H-thiazolo[2,3-b]quinazoline-3-one via 1,3-dipolar cycloaddition to give nine fused quinazoline spiro-heterocyclic compounds. The configuration and conformation of the products were determined by elementary analysis, ¹H NMR, IR and X-ray crystal analysis. The results also revealed that the reaction was stereospecific.

Key words: Spiro-heterocycle, Azomethine ylide, Cycloaddition, Synthesis

CLC Number:

O626

TrendMD:

LI Xiao-Fang, FENG Ya-Qing, YOU Xu-Dong, HU Xiao-Fen. Synthesis and Crystal Structure of the Fused Quinazoline Spiro-heterocyclic Compounds[J]. Chem. J. Chinese Universities, 2005, 26(2): 270.

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Synthesis and Crystal Structure of the Fused Quinazoline Spiro-heterocyclic Compounds

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