Effect of Lanthanides on the Interaction Between Recombinant Endostatin and Heparin

Abstract

Abstract: The interaction of recombinant endostatin with lanthanides and heparin was studied by fluorescence and CD spectra. The results indicate that the binding of lanthanides, heparin to recombinant endostatin(rhES) causes quenching of its fluorescence and conformational changes of rhES.The binding of lanthanides to rhES can affect the interaction between its protein and heparin and decrease the inhibiting activity of rhES to the proliferation of human umbilical vein endothelial cell.

Key words: Recombinant endostatin, Fluorescence spectra, Circular dichroism spectra, Lanthanides, Endothelial cell

CLC Number:

O614

TrendMD:

WANG Qun, NI Jia-Zuan, . Effect of Lanthanides on the Interaction Between Recombinant Endostatin and Heparin[J]. Chem. J. Chinese Universities, 2004, 25(10): 1783.

References

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