Preparation and in Vitro Release of Rifampin Microspheres Encapsulated in Biodegradable Polyesters

Abstract

Abstract: Microspheres containing antiphthisic drug Rifampin were prepared from poly(lactide-co-glycolide) (PLGA) as carrier by emulsion and solvent evaporation method. The conditions of the microsphere preparation such as the drug/carrier molar ratio, the volume ratio of organic solvent to water, PLGA concentration in organic solvent, speed of emulsification, kind of stabilizer, relative molecular weight of {PLGA}, LLA/GA mass ratio were discussed. The surface morphology of the microspheres in original and degraded states was observed by SEM. The mean diameter and drug content of microspheres were examined, and the drug release %in vitro% was evaluated. The morphology of the microspheres prepared from {PLGA} and by 1% gelatin as the stabilizer was integral with 10—30 μm diameter range, 24.3% average drug content, 42—84 d drug-release time. The drug-release kinetics with zero order satisfies the requirements of controlled drug-release.

Key words: Rifampin, PLGA, Microspheres, Biodegradable polymer, Controlled drug-release, Lung targeting

CLC Number:

O631

TrendMD:

YANG Ya-Nan, LOU Ling, LIANG Qi-Zhi, CHEN Xue-Si, JING Xia-Bin . Preparation and in Vitro Release of Rifampin Microspheres Encapsulated in Biodegradable Polyesters[J]. Chem. J. Chinese Universities, 2004, 25(1): 162.

[1]	WANG Xuebin, XUE Yuan, MAO Hua’nyu, XIANG Yanxin, BAO Chunyan. Preparation of Photo/reduction Dual-responsive Hydrogel Microspheres and Their Application in Three-dimensional Cell Culture [J]. Chem. J. Chinese Universities, 2022, 43(8): 20220116.
[2]	FAN Ye, HAN Huihui, FANG Yun, FENG Ruiqin, XIA Yongmei. Facile Synthesis of Hollow Nickel Submicrospheres with Hierarchical Nano-structure and Its Catalytic Hydrogenation of Phenol [J]. Chem. J. Chinese Universities, 2021, 42(6): 1801.
[3]	HUANG Xiaolin,XIE Huan,CAO Hong,JIN Hongjie,LI Chun,WU Tinghua. Preparation, Characterization of Magnetic Core Gel Microspheres Loaded Ionic Liquids and Its Application in Cells Immobilization Technique^† [J]. Chem. J. Chinese Universities, 2019, 40(4): 793.
[4]	TANG Bo,HUANG Hao,WU Bing,LI Xu,WANG Xiaogong. Self-assembled Azo Molecular Glass Microspheres with Rapid Photoinduced Deformation^† [J]. Chem. J. Chinese Universities, 2019, 40(3): 548.
[5]	DUAN Bingyi,WANG Yu,GUO Ningning,WANG Runwei,ZHANG Zongtao,QIU Shilun. Preparation of Yolk-shell Fe₃O₄@SiO₂@PMO Magnetic Microspheres for Laccase Immobilization^† [J]. Chem. J. Chinese Universities, 2019, 40(2): 210.
[6]	LIU Yaoshan,WU Hailin,JIA Zhi,DU Bo,LIU Dayong,ZHOU Zhimin. Silk Fibroin-modified Ploylactic Acid-glycolic Acid Copolymer Porous Microspheres as Gingival Mesenchymal Stem Cells Delivery Carrier ^† [J]. Chem. J. Chinese Universities, 2019, 40(11): 2419.
[7]	YUAN Baoming,DONG Xiaoming,YANG Fan,PENG Chuangang,WANG Jincheng,Wu Dankai. Preparation and the Antibacterial Activity of AgNPs/PLGA-PEG-PLGA Composite Hydrogel ^† [J]. Chem. J. Chinese Universities, 2019, 40(10): 2225.
[8]	MA Qinghai,CUI Fang,LIU Mufei,XU linxu,ZHANG Jiajia,CUI Tieyu. Synthesis and Catalytic Performance of Pd/PdO Nanocomposite Microspheres ^† [J]. Chem. J. Chinese Universities, 2019, 40(10): 2041.
[9]	WANG Fuxiang,CHEN Ziyu,YANG Weiting,LIU Lijuan,REN Guojian,LIU Yanfeng,PAN Qinhe. Preparation and Adsorption Performance for U(Ⅵ) of ZnO@ZIF-8 Core@Shell Microspheres^† [J]. Chem. J. Chinese Universities, 2019, 40(1): 24.
[10]	TONG Yongchun, WANG Qingyun, BAI Qingling, LI Zhen, JIA Chuanming. Preparation of Inorganic-organic Composite Hollow Microspheres by Double Pickering Emulsion Template^† [J]. Chem. J. Chinese Universities, 2018, 39(7): 1462.
[11]	DENG Caisong, PAN Tingting, DU Lan, WANG Ming, NI Haibin, NI Xiaoqi. Fabrication of Monolayer Crystalline Films on Optical Fiber End by Micro-flow Injection Method^† [J]. Chem. J. Chinese Universities, 2018, 39(4): 708.
[12]	DONG Xiaoming, YUAN Baoming, CHEN Bingpeng, HE Chaoliang, WANG Jincheng, CHEN Xuesi. In vitro Antibacterial Activity of PLGA-PEG-PLGA Thermosensitive Hydrogels Loaded with Vancomycin [J]. Chem. J. Chinese Universities, 2017, 38(5): 866.
[13]	LI Guangyao, WANG Yu, CAO Yinliang, XIAO Zhongliang, HUANG Ying, FENG Zemeng, YIN Yulong, CAO Zhong. SnO₂ Hollow Microspheres Used for Rapid and Sensitive Detection of Hydrogen Sulfide^† [J]. Chem. J. Chinese Universities, 2017, 38(11): 1953.
[14]	YANG Junxing, WANG Qi, WANG Yuanyuan, HAN Shu, YAO Jiawei, SHAO Siqi, WANG Jinglong, LIU Zhihui, GUO Yupeng. Preparation and in vitro Release of Multilayer Alginate Chitosan Microspheres Loading VEGF and Vancomycin^† [J]. Chem. J. Chinese Universities, 2015, 36(5): 1025.
[15]	REN Zhiyu, LI Zhongtao, DU Shichao, WU Jun, KONG Lingjun, FU Honggang. Synthesis of Ag/mSiO₂ Hollow Microspheres for SERS-tags^† [J]. Chem. J. Chinese Universities, 2014, 35(7): 1541.

Preparation and in Vitro Release of Rifampin Microspheres Encapsulated in Biodegradable Polyesters

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments