A New Facile Synthesis Method of Branched PEG

Abstract

Abstract: The modification of bioactive proteins (peptides, enzymes) by using polyethylene glycol(PEG) has still been a hot filed of research.It has been reported that branched PEG is distinctly superior to linear PEG in the modification of some enzymes.However the existing synthetic methods of branched PEG make it very expensive to be used in research and practice.In this paper, a kind of branched PEG was synthesized via conventional methods used in the synthesis of polypeptide(protection, condensation, and deprotection) using lysine and m PEG5000 as starting materials.In this method, the most important reaction of forming branched PEG was fulfilled in one step by condensation reaction in organic phase.It makes this method remarkably different from other methods.The reaction condition is mild and the yield of the product(61%) is higher.The characterization of products in different steps is consistent with their structures.The ¹HNMR spectrum of our end product branched PEG tallies with its structure.

Key words: New method, Synthesis, Branched PEG

CLC Number:

O633.1

TrendMD:

HE Ming-Lei, SU Zhi-Guo  . A New Facile Synthesis Method of Branched PEG[J]. Chem. J. Chinese Universities, 2003, 24(8): 1495.

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A New Facile Synthesis Method of Branched PEG

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