Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (8): 1430.

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Synthesis and Cleaving Activity of DNA Photocleaver Containing Bromoacetophenone

LI Li-Hua, LIU Dan, TANG Fei-Li, YUAN Gu   

  1. Key Laboratory of Bioorganic and Molecular Engineering of Education Ministry, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
  • Received:2002-08-29 Online:2003-08-24 Published:2003-08-24

Abstract: Anovel DNA photocleaver containing bromoacetophenone-polyamide was synthesized by DCC coupling reaction in the presence of DMAP, and its DNA cleaving activity was investigated by using pBluescript SK DNA by method of gelelectrophoresis.The result shows that the photocleaver containing bromoacetophenone-polyamide has a remarkable cleaving activity for pBluescript SK DNA.

Key words: Polyamide, DNA recognition molecules, DNA-photocleavage agents

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