Relationships Between Structure and Activity for Flavonoids to Lipid Peroxidation in Liver Microsomer from Rat

Abstract

Abstract: IC₅₀values of 13 flavonoids to lipid peroxidation induced by OH^·in liver microsomer from rat were evaluated and the relationship between structure and activity was studied. The flavonoids with catechol group, which usually have a higher energy in the highest occupied molecular orbital and lower ΔHOF values, have higher inhibitory activities than those without catechol group. The flavonoids without catechol group in Bring not being suitable structure to chelate with Fe²⁺have little inhibitory activities. The results suggest the anti-lipid peroxidation activity of flavonoids is related with the structure of flavonoids.

Key words: Flavonoid, Liver microsomer, Lipid peroxidation, Relationship between structure and activity

CLC Number:

O626

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JIANG Hui-Di, FANG Wei-Jie, FU Xu-Chun, LIU Feng-Lan, HU Yong-Zhou . Relationships Between Structure and Activity for Flavonoids to Lipid Peroxidation in Liver Microsomer from Rat[J]. Chem. J. Chinese Universities, 2003, 24(12): 2221.

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Relationships Between Structure and Activity for Flavonoids to Lipid Peroxidation in Liver Microsomer from Rat

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