Design of New Polypyridyl Ligands and Their Effects on DNA-binding Mechanisms of Complexes

Abstract

Abstract: Two structurally related polypyridyl ligands ODHIP(3,4-dihydroxyl-imidazophenanthroline), MDHIP(2,4-dihydroxyl-imidazo phenanthroline) and their ruthenium(II) complexes [Ru(phen)₂ODHIP]²⁺and [Ru(phen)₂MDHIP]²⁺were prepared and characterized.Their DNA-binding properties were studied by spectroscopic methods and viscosity measurements.The results indicated that the two complexes are bound to DNA by different modes due to the different planarities of ligands.For the complex [Ru(phen)₂MDHIP] ²⁺, the 2-position ortho group of MDHIP could form an intramolecular hydrogen bond with the nitrogen atom of the imidazole ring to extend the planarity and strengthen the binding affinity.On the other hand, the 4-position ortho group hindered the complex from intercalating into the base pairs of DNA, and finally, making the complex bind to DNA by a partial intercalative mode.However, for the complex [Ru(phen)₂ODHIP]²⁺, there was no intramolecular hydrogen bond formed and the two ortho groups further increased the steric effect and decreased the binding affinity, thus making the complex bind to DNAby groove binding mode.

Key words: Polypyridyl ruthenium complex, DNA, Intercalation, Groove binding

CLC Number:

O614

TrendMD:

ZHANG Qian-Ling, LIU Jian-Hong, LIU Jian-Zhong, REN Xiang-Zhong, ZHANG Pei-Xin, WEI Bo, XU Hong, JI Liang-Nian . Design of New Polypyridyl Ligands and Their Effects on DNA-binding Mechanisms of Complexes[J]. Chem. J. Chinese Universities, 2003, 24(10): 1753.

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Design of New Polypyridyl Ligands and Their Effects on DNA-binding Mechanisms of Complexes

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