CJCU

Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (1): 21.

• Preface • Previous Articles     Next Articles

The Preparation and Biodistribution of a New Potential Myocardial Imaging Agent: Technetium-99m Labeled[Tc(CO)3(TBI)3]+ Complex

ZHANG Xian-Zhong, WANG Xue-Bin, WEN Hai-Tao   

  1. Department of Chemistry, Beijing Normal University, Beijing 100875, China
  • Received:2002-04-16 Online:2003-01-24 Published:2003-01-24

PDF (PC)

Abstract: Starting from [99mTcO4]- and at a pressure of 0.1 MPa, the important starting material[99mTc(CO)3(H2O)3] + is synthesized. By ligand exchanging of this starting material with isonitrile ligand TBI (t-butyl-isonitrile), the complex [99mTc(CO)3(TBI)3]+ is prepared with a labeling yield higher than 90%, and it is stable over 6 h at room temperature. The biodistribution of this new complex in normal mice indicates that it is well accumulated and maintained in heart. The values of its heart uptake at 5 and 60 min post-injection time are (19.07±0.81)%(ID/g) and (18.24±2.41)%(ID/g), respectively. The uptake ratios of heart to liver, lung, and blood at 60 min post-injection time are 1.02, 5.83 and 23.69, respectively. Its good properties and easy availability make it a very promising myocardial imaging agent.

Key words: Tc(Ⅰ)-carbonyl complex, Myocardial imaging agent, t-Butyl isonitrile(TBI), Biodistribution in mice, Radiolabeling

CLC Number: 

TrendMD: