Abstract: Liposome encapsulated polyoxometalate α-K₈H₆[Si₂W₁₈Ti₆O₇₇](α-Si₂W₁₈Ti₆) was synthesized by using liposomal encapsulating method. The structure of nanomaterial were characterized by IR spectra, solid NMR spectra and polarography, and the forms and range in size of the nanomaterial were estimated by using TEM and Zetasizer. The results show that the polyoxometalate in the complex retains its parent structure, and the sizes of the complexes are from 60 to 150 nm. By using MTT method, the antitumoral activities of the complexes were assayed. The results showed that after being encapsulated by the liposome, the stability and antitumoral activity of polyoxometalate were enhanced.

Key words: Liposome nanaparticle, Heteropoly acid compound, Antitumoral activity in vitro